Association of adiponectin and resistin with adipose tissue compartments, insulin resistance and dyslipidaemia

  1. M. S. Farvid1,
  2. T. W. K. Ng2,
  3. D. C. Chan2,
  4. P. H. R. Barrett2,
  5. G. F. Watts2,*

Article first published online: 24 NOV 2004

DOI: 10.1111/j.1463-1326.2004.00410.x

Issue

Diabetes, Obesity and Metabolism

Diabetes, Obesity and Metabolism

Volume 7, Issue 4, pages 406–413, July 2005

Additional Information

How to Cite

Farvid, M. S., Ng, T. W. K., Chan, D. C., Barrett, P. H. R. and Watts, G. F. (2005), Association of adiponectin and resistin with adipose tissue compartments, insulin resistance and dyslipidaemia. Diabetes, Obesity and Metabolism, 7: 406–413. doi: 10.1111/j.1463-1326.2004.00410.x

Author Information

  1. 1

    School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

  2. 2

    School of Medicine and Pharmacology, Western Australia Institute of Medical Research, University of Western Australia, Royal Perth Hospital, Perth, Australia

* Prof Gerald F. Watts, School of Medicine and Pharmacology, The Western Australia Institute for Research, University of Western Australia, Royal Perth Hospital, GPO Box X2213, Perth, WA 6847, Australia. E-mail: gfwatts@cyllene.uwa.edu.au

Publication History

  1. Issue published online: 24 NOV 2004
  2. Article first published online: 24 NOV 2004
  3. Received 4 April 2004; returned for revision 18 May 2004; revised version accepted 18 May 2004

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Keywords:

  • adiponectin;
  • dyslipidaemia;
  • fat compartments;
  • insulin resistance;
  • resistin

Aim:  In this study, we investigated the association of plasma adiponectin and resistin concentrations with adipose tissue compartments in 41 free-living men with a wide range of body mass index (22–35 kg/m2).

Methods:  Using enzyme immunoassays, plasma adiponectin and resistin were measured. Intraperitoneal, retroperitoneal, subcutaneous abdominal and posterior subcutaneous abdominal adipose tissue masses (IPATM, RPATM, SAATM and PSAATM, respectively) were determined using magnetic resonance imaging. Total adipose tissue mass (TATM) was measured using bioelectrical impedance. Insulin resistance was estimated with the help of homeostasis model assessment (HOMA) score.

Results:  In univariate regression, plasma adiponectin levels were inversely related to IPATM (r = −0.389, p < 0.05), SAATM (r = −0.500, p < 0.001), PSAATM (r = −0.502, p < 0.001), anterior SAATM (r = −0.422, p < 0.01) and TATM (r = −0.421, p < 0.01). In multiple regression models, adiponectin was chiefly correlated with PSAATM. Plasma adiponectin concentrations were also inversely correlated with HOMA score (r = −0.540, p < 0.001) and triglyceride (r = −0.632, p < 0.001), and positively correlated with high-density lipoprotein cholesterol (r = 0.508, p < 0.001). There were no significant correlations between resistin levels and adipose tissue masses, insulin resistance or dyslipidaemia.

Conclusions:  In men, total body fat is significantly correlated with plasma adiponectin, but not with plasma resistin levels. Low plasma adiponectin levels appear to be chiefly determined by the accumulation of posterior subcutaneous abdominal fat mass, as opposed to intra-abdominal fat, and are strongly predictive of insulin resistance and dyslipidaemia.

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