microRNAs and the regulation of glucose and lipid metabolism

  1. M. N. Poy,
  2. M. Spranger,
  3. M. Stoffel*

Article first published online: 4 OCT 2007

DOI: 10.1111/j.1463-1326.2007.00775.x

Issue

Diabetes, Obesity and Metabolism

Diabetes, Obesity and Metabolism

Volume 9, Issue Supplement s2, pages 67–73, November 2007

Additional Information

How to Cite

Poy, M. N., Spranger, M. and Stoffel, M. (2007), microRNAs and the regulation of glucose and lipid metabolism. Diabetes, Obesity and Metabolism, 9: 67–73. doi: 10.1111/j.1463-1326.2007.00775.x

Author Information

  1. Institute of Molecular Systems Biology, and Competence Center for Systems Physiology and Metabolic Diseases, Swiss Federal Institute of Technology Zürich, Zürich, Switzerland

*Markus Stoffel, MD, PhD, Institute of Molecular Systems Biology, and Competence Center for Systems Physiology and Metabolic Diseases, Swiss Federal Institute of Technology Zürich, HPT E73, Wolfgang Pauli Strasse 16, CH-8093 Zürich, Switzerland. E-mail: stoffel@imsb.biol.ethz.ch

Publication History

  1. Issue published online: 4 OCT 2007
  2. Article first published online: 4 OCT 2007
  3. Received 4 April 2007; accepted 29 May 2007

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Keywords:

  • adipocyte;
  • brain;
  • glucose;
  • insulin;
  • lipid;
  • liver;
  • metabolism;
  • microRNAs;
  • muscle

Over recent years, metabolic disorders such as type 2 diabetes have finally become recognized as a major challenge to global health. The attention of scientists therefore has to focus on improving our understanding of the molecular mechanisms behind these diseases and towards the design of new drug therapy strategies. The pathophysiology of diabetes is undoubtedly complex, oftentimes characterized by varying states of insulin resistance and impaired β-cell function; however, the identification of new pathways is constantly improving our understanding of the disease. We and others have recently shown that microRNAs (miRNAs) can play a role in insulin secretion and glucose homostasis. Thus, in this review, we will discuss the potential role of miRNAs in type 2 diabetes and related metabolic diseases.

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