Regulation of pancreatic β-cell function by the forkhead protein FoxO1

Authors


  • Conflicts of Interest:
    All authors declare no conflicts of interest.

Dr Domenico Accili, Department of Medicine, Columbia University Medical Center, 1150 St Nicholas Avenue, New York, NY 10032, USA.
E-mail:
da230@columbia.edu

Abstract

Forkhead transcription factors of the FoxO family play a critical role in cellular differentiation, proliferation, apoptosis and stress resistance. FoxO1 regulates glucose and lipid production in liver; food intake in the hypothalamus and cell differentiation in preadipocytes, myoblasts and vascular endothelium. In this review, we summarize recent literature on the role of FoxO1 in pancreatic β cells. FoxO1 regulates β-cell proliferation and protects against β-cell failure induced by oxidative stress through NeuroD and MafA induction. In addition, FoxO1 nuclear exclusion is required for the proliferative effects of glucoincretin glucagon-like peptide-1 in islets. The data begin to outline an overarching role of FoxO1 in β-cell function.

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