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Uveodermatologic lymphoma in two young related Portuguese water dogs

Authors

  • Natàlia Escanilla,

    1. Servei d’Oftalmologia Veterinària, Fundació Hospital Clínic Veterinari, Departament de Medicina i Cirurgia Animals, Facultat de Veterinària, Universitat Autònoma de Barcelona, Campus de la UAB, Edifici V. 08193. Bellaterra, Barcelona, Spain
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  • Marta Leiva,

    1. Servei d’Oftalmologia Veterinària, Fundació Hospital Clínic Veterinari, Departament de Medicina i Cirurgia Animals, Facultat de Veterinària, Universitat Autònoma de Barcelona, Campus de la UAB, Edifici V. 08193. Bellaterra, Barcelona, Spain
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  • Laura Ordeix,

    1. Servei de Dermatologia Veterinària, (Univet). Avenida Cerdanyola 92. 08172 Sant Cugat del Valles, Barcelona, Spain, Clinica Ars Veterinaria. Carrer Cardedeu 3. 08023 Barcelona, Spain
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    • Present address: Hospital Ars Veterinaria and UNIVET S.L. Servicio de diagnóstico dermatológico, Barcelona, Spain.

  • Teresa Peña

    1. Servei d’Oftalmologia Veterinària, Fundació Hospital Clínic Veterinari, Departament de Medicina i Cirurgia Animals, Facultat de Veterinària, Universitat Autònoma de Barcelona, Campus de la UAB, Edifici V. 08193. Bellaterra, Barcelona, Spain
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Address communications to:
T. Peña
Tel.: +34-93-581-1387
Fax: +34-93-581-3428
e-mail: teresa.pena@uab.cat

Abstract

Purpose  Canine lymphoma (CL) is one of the most common forms of spontaneous canine neoplasia. Improved understanding of the genetic and environmental factors associated with CL may provide benefits for the study of non-Hodgkin’s and Hodgkin’s lymphoma in humans. Uveodermatologic lymphoma is reported in a single household of Portuguese water dog, and the etiology is discussed.

Methods  A 1-year-old female intact Portuguese water dog was referred to the Ophthalmology Service of the Veterinary Teaching Hospital of the Autonomous University of Barcelona because of acute blepharospasm of the right eye in association with a multinodular dermatosis. Physical and ophthalmological examination and a complete diagnostic work-up, including skin and ocular histopathology and immunohistochemistry, were performed. Three months prior, in Galicia (Spain), 1200 km away from Barcelona, a male dog of the same litter showed very similar oculodermatological clinical signs and skin histopathology, and immunohistochemistry were obtained.

Results  The clinical diagnoses were anterior exudative uveitis, iridal masses, and secondary glaucoma. Histopathology and immunohistochemistry revealed a nonepitheliotropic lymphoma rich in B cell in dog 1 and rich in T cell in dog 2.

Conclusion  It is proposed that an underlying genetic predisposition could have played a role in the development of lymphoma in these two young related dogs.

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