In their paper, Cervone, Shadel, Smith, and Fiori (2006) present a thorough analysis of self-regulatory behavior, understood as the most genuine expression of the agentic and purposive nature of human beings. Therefore, we can expect that research on personality could shed light on our understanding of self-regulatory processes and behavioral expressions. With this aim, Cervone et al. have carried out an updated analysis of personality psychology theory and research, resuming the debate between variable and person-centered approaches, and commenting on the contributions the Knowledge-and-Appraisal Personality Architecture (KAPA) can make to the design of idiosyncratic tools and strategies for personality assessment and to the understanding of the role of the personality system in different contexts of applied psychology, such as health, clinical and industrial/organisational psychology. Here, I would like to examine two topics, to which Cervone et al. pay substantial attention in their paper: self-regulation and personality dynamics, and the role of personality science in addressing central questions in health psychology.