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Summary— Experimental models to represent the surgical methods of bladder transection in humans were performed on dogs and rabbits. The effects on vesical neurophysiology were studied by cystometry with bethanechoI supersensitivity testing; by in vitropharmacoIogicaI responsiveness; by determination of autonomic receptor densities using radio-ligand binding and by autonomic neurohistochemical staining. Analysis revealed that transection with or without neurovascular preservation resulted in an alpha-adrenergic denervation and cholinergic decentralization. A comparison with the surgical models is presented and proposed mechanisms of action are discussed in relation to the experimental results.