K. E. Creed, PhD, Senior Lecturer in Physiology, School of Veterinary Studies.
The Action of Imipramine on the Lower Urinary Tract of the Dog
Article first published online: 26 NOV 2008
© 1982 British Association of Urological Surgeons
British Journal of Urology
Volume 54, Issue 1, pages 5–10, February 1982
How to Cite
CREED, K. E. and TULLOCH, A. G. S. (1982), The Action of Imipramine on the Lower Urinary Tract of the Dog. British Journal of Urology, 54: 5–10. doi: 10.1111/j.1464-410X.1982.tb13502.x
- Issue published online: 26 NOV 2008
- Article first published online: 26 NOV 2008
- Accepted for publication 14 July 1980
Summary— Imipramine at 1 mg/kg body weight reduced contractions of the urethra and bladder produced in response to pelvic nerve stimulation by 58 and 56% in female anaesthetised dogs. Responses to injection into the internal iliac artery of acetylcholine, histamine and 5 hydroxytryptamine (5HT) were also reduced but those to ATP and noradrenaline were not altered. Atropine (0.1 mg/kg) blocked responses to acetylcholine and pelvic nerve stimulation but was without action on responses to ATP, histamine or 5HT. Mepyramine (1 mg/kg) but not metiamide (0.5 mg/kg) selectively blocked responses to histamine. The responses to pelvic nerve stimulation or acetylcholine were not altered.
It was concluded that imipramine does not have significant anticholinergic action and is unlikely to block uptake of biogenic amines. The powerful inhibitory action on histamine responses could reduce the effects of circulating histamine but cannot explain the reduction of the nerve-induced response.