Generalised Increase in Bone Resorption in Carcinoma of the Prostate

Authors

  • G. H. URWIN,

    1. University Departments of Human Metabolism and Clinical Biochemistry, and Pathology, University of Sheffield; Department of Urology, Royal Hallamshire Hospital, Sheffield
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    • 2

      G. H. Urwin, FRCS, Wellcome Surgical Research Fellow.

  • R. C. PERCIVAL,

    1. University Departments of Human Metabolism and Clinical Biochemistry, and Pathology, University of Sheffield; Department of Urology, Royal Hallamshire Hospital, Sheffield
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    • 3

      R. C. Percival, FRCS, Lecturer in Surgery. Northern General Hospital, Sheffield.

  • S. HARRIS,

    1. University Departments of Human Metabolism and Clinical Biochemistry, and Pathology, University of Sheffield; Department of Urology, Royal Hallamshire Hospital, Sheffield
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      S. Harris, MB, BCh, Lecturer in Pathology.

  • M. N. C. BENETON,

    1. University Departments of Human Metabolism and Clinical Biochemistry, and Pathology, University of Sheffield; Department of Urology, Royal Hallamshire Hospital, Sheffield
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    • 5

      M. Beneton, HNC, Research Assistant.

  • J. L. WILLIAMS,

    1. University Departments of Human Metabolism and Clinical Biochemistry, and Pathology, University of Sheffield; Department of Urology, Royal Hallamshire Hospital, Sheffield
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      J. L. Williams, FRCS, Consultant Urologist.

  • J. A. KANIS

    Corresponding author
    1. University Departments of Human Metabolism and Clinical Biochemistry, and Pathology, University of Sheffield; Department of Urology, Royal Hallamshire Hospital, Sheffield
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    • 7

      J. A. Kanis, MD, FRCP, MRCPath, Reader in Human Metabolism and Clinical Biochemistry.


Department of Human Metabolism and Clinical Biochemistry, University of Sheffield Medical School, Beech Hill Road, Sheffield SIO 2RX.

Abstract

Summary— Several indirect biochemical indices of bone resorption are increased in patients with carcinoma of the prostate and skeletal metastases. We have examined histological indices of bone resorption in biopsies from affected patients. Bone-forming surfaces and active osteoblast numbers were increased in skeletal sites adjacent to tumour tissue and indices of bone resorption were significantly increased at sites adjacent to tumour. Contrary to expectation, indices of bone resorption were also increased in bone distant from skeletal metastases. These findings suggest that prostatic cancer induces generalised loss of trabecular bone which may minimise disturbances in plasma calcium homeostasis but could contribute to morbidity.

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