MD, Research Director, Central Research Unit of General Practice.
Prophylactic Treatment of Adult Nocturia with Bumetanide
Article first published online: 21 NOV 2008
British Journal of Urology
Volume 62, Issue 2, pages 145–147, August 1988
How to Cite
PEDERSEN, P. A. and JOHANSEN, P. B. (1988), Prophylactic Treatment of Adult Nocturia with Bumetanide. British Journal of Urology, 62: 145–147. doi: 10.1111/j.1464-410X.1988.tb04294.x
- Issue published online: 21 NOV 2008
- Article first published online: 21 NOV 2008
- Accepted for publication 12 October 1987
Summary— The efficacy of 1 mg bumetanide on nocturia was compared with placebo in a randomised double-blind cross-over study in general practice. Twenty-eight patients, 13 females and 15 males, completed two treatment periods of 2 weeks' duration. During the placebo period the weekly number of nocturia episodes was 13.8 and during bumetanide treatment the number was reduced by 3.8. Ten males had a history of prostatic hypertrophy and in these patients treatment with bumetanide was not beneficial. In the remaining 18 patients the weekly number of nocturia episodes was reduced by 4 during bumetanide treatment compared with the placebo period. Of these patients, 3 preferred treatment with placebo, 11 preferred bumetanide and 4 gave no preference. These results suggest that bumetanide offers an alternative in the treatment of adult nocturia not connected with enlargement of the prostate.