Larrian Gillespie, MD, Clinical Instructor, Urology, University of California at Irvine; Director of the Women's Clinic for Interstitial Cystitis, Beverly Hills, California.
Immunofluorescentand Histochemical Staining Confirm the Identification of the Many Diseases Called Interstitial Cystitis
Article first published online: 26 NOV 2008
© 1990 British Journal of Urology
British Journal of Urology
Volume 66, Issue 3, pages 265–273, September 1990
How to Cite
GILLESPIE, L., SAID, J., SOSTRIN, S. and KLEIWER, K. (1990), Immunofluorescentand Histochemical Staining Confirm the Identification of the Many Diseases Called Interstitial Cystitis. British Journal of Urology, 66: 265–273. doi: 10.1111/j.1464-410X.1990.tb14924.x
- Issue published online: 26 NOV 2008
- Article first published online: 26 NOV 2008
- Accepted for publication 13 September 1989
Summary— Interstitial cystitis comprises a complex of diseases typified by symptoms of pelvic pain. Functional complaints do not aid the clinician in determining loss of anatomical capacity. Histochemical staining with PAS-colloidal iron/Van Geison's counterstain offers improved diagnostic ability for the pathologist and correlates well with immunofluorescent findings. Four distinct diseases can be identified through immunofluorescent staining, indicating that each is the result of different responses of the urothelium and endothelium to injury. Loss of bladder capacity associated with these diseases can be expected with age, but immunofluorescent staining for IgM within the capillaries of the interstitium is a more sensitive predictor.