S. C. W. Harrison, MA, MChir, FRCS, formerly Research Registrar in Urology, Addenbrooke's Hospital. Now Senior Registrar in Urology, Southmead Hospital, Bristol.
Effect of Bladder Outflow Obstruction on the Innervation of the Rabbit Urinary Bladder
Article first published online: 26 NOV 2008
© 1990 British Journal of Urology
British Journal of Urology
Volume 66, Issue 4, pages 372–379, October 1990
How to Cite
HARRISON, S. C. W., FERGUSON, D. R. and DOYLE, P. T. (1990), Effect of Bladder Outflow Obstruction on the Innervation of the Rabbit Urinary Bladder. British Journal of Urology, 66: 372–379. doi: 10.1111/j.1464-410X.1990.tb14957.x
- Issue published online: 26 NOV 2008
- Article first published online: 26 NOV 2008
- Accepted for publication 23 February 1990
Summary— The effects of bladder outflow obstruction on the innervation of the bladder were studied using a rabbit animal model. Partial occlusion of the bladder neck was obtained by the placement of a silk ligature at that level; control animals underwent a sham procedure. After a 3-month period, the presence of outflow tract obstruction was confirmed using urodynamic studies. The animals were then killed and pharmacological assessments of the bladder innervation undertaken.
Detrusor muscle strip studies provided evidence of damage to the cholinergic innervation of the detrusor. Also, muscle strips from obstructed animals showed reduced inhibitory responses to p-adrenergic stimulation with isoprenaline. In addition to these muscle strip studies, the bladder content of the neuropeptide substance P was assayed, but no significant change was observed in response to obstruction. This finding suggests that substance P-containing sensory nerves may be spared from the denervating effect of bladder outflow obstruction.