B. Waymont, FRCS, Urological Research Registrar, CRC Trials Unit, Queen Elizabeth Hospital.
Phase III Randomised Study of Zoladex versus Stilboestrol in the Treatment of Advanced Prostate Cancer
Article first published online: 26 NOV 2008
© 1992 British Journal of Urology
British Journal of Urology
Volume 69, Issue 6, pages 614–620, June 1992
How to Cite
WAYMONT, B., LYNCH, T. H., DUNN, J. A., EMTAGE, L. A., ARKELL, D. G., WALLACE, D. M. A. and BLACKLEDGE, G. R. P. (1992), Phase III Randomised Study of Zoladex versus Stilboestrol in the Treatment of Advanced Prostate Cancer. British Journal of Urology, 69: 614–620. doi: 10.1111/j.1464-410X.1992.tb15633.x
- Issue published online: 26 NOV 2008
- Article first published online: 26 NOV 2008
- Accepted for publication 18 July 1991
Summary— An open randomised Phase III trial was conducted of the depot GnRH analogue goserelin (Zoladex) versus stilboestrol (3 mg/day) in patients with advanced or metastatic prostate cancer. The study included 250 patients and the median follow-up was 43 months. In the Zoladex arm the time to first response was achieved earlier and more patients reported an improvement in symptoms. There was no statistically significant difference between the Zoladex and the stilboestrol arms with regard to survival and time to treatment failure.
A major reason for treatment failure was the preponderance of adverse events in patients receiving stilboestrol. It is suggested that stilboestrol should no longer be used for prostate cancer when equally effective alternative treatments are available.