P. Teillac, MD, Professor, Hôpital St Louis.
Urinary Flow Rates in Patients with Benign Prostatic Hypertrophy following Treatment with Alfuzosin
Article first published online: 26 NOV 2008
© 1992 British Journal of Urology
British Journal of Urology
Volume 70, Issue 1, pages 58–64, July 1992
How to Cite
TEILLAC, P., DELAUCHE-CAVALLIER, M. C. and Group, P. A. a. t. D. (1992), Urinary Flow Rates in Patients with Benign Prostatic Hypertrophy following Treatment with Alfuzosin. British Journal of Urology, 70: 58–64. doi: 10.1111/j.1464-410X.1992.tb15665.x
- Issue published online: 26 NOV 2008
- Article first published online: 26 NOV 2008
- Accepted for publication 11 December 1991
Summary— In order to document further the onset of action of alfuzosin, a selective alpha-1 blocker, 93 symptomatic patients with benign prostatic hypertrophy were randomly allocated to a single oral dose of either alfuzosin 1.25 mg or 2.5 mg, or placebo, after a 1-week placebo lead-in period. The effects on flow rates were assessed 1 h 30 min after administration. Peak and mean flow rates were significantly increased in the alfuzosin groups, as compared with placebo, in a dose-dependent manner. After a single intake of placebo, the mean values of these 2 parameters showed little change. The effect on the cardiovascular system (heart rate and blood pressure) was mild. This study indicates that the action of alfuzosin is already present 1 h 30 min after administration.