Rapid tumour recurrence following cessation of long-term treatment with intravesical thiotepa
Article first published online: 26 NOV 2008
© 1994 British Journal of Urology
British Journal of Urology
Volume 74, Issue 1, pages 44–46, July 1994
How to Cite
MUKAMEL, E. and SERVADIO, C. (1994), Rapid tumour recurrence following cessation of long-term treatment with intravesical thiotepa. British Journal of Urology, 74: 44–46. doi: 10.1111/j.1464-410X.1994.tb16544.x
- Issue published online: 26 NOV 2008
- Article first published online: 26 NOV 2008
- Accepted for publication 9 september 1993
- transitional cell carcinoma
Objective To report tumour recurrence related to cessation of long-term therapy with thiotepa.
Patients and methods A group of 12 patients with low grade (I-II). low stage (TA-T1) transitional cell carcinoma of the bladder were included in the study. All patients had been treated with intravesical thiotepa for a period ranging from 24 to 71 months and none had had a recurrence for a period of between 15 and 51 months. After referral to this department all the patients were withdrawn from thiotepa therapy.
Results All the patients developed bladder tumours within 6 months of cessation of therapy. The recurrent tumours were grade II in 10 patients grade III in two patients. Eight patients had stage TA and four had stage T1. All responded to bacille Calmette-Guérin therapy and none had tumour recurrence on follow up at 24 months.
Conclusion Meticulous follow-up of patients is indicated soon after the cessation of long-term therapy with thiotepa.