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DCC protein expression in clear cell renal cell carcinoma
Article first published online: 25 MAR 2004
DOI: 10.1111/j.1464-410X.2003.04730.x
Additional Information
How to Cite
Dekel, Y., Kugel, V., Livne, P., Gal, R. and Koren, R. (2004), DCC protein expression in clear cell renal cell carcinoma. BJU International, 93: 867–869. doi: 10.1111/j.1464-410X.2003.04730.x
Publication History
- Issue published online: 25 MAR 2004
- Article first published online: 25 MAR 2004
- Accepted for publication 10 November 2003
- Abstract
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Keywords:
- DCC expression;
- RCC;
- prognosis;
- survival
OBJECTIVES
To investigate whether the expression of protein from the ‘deleted in colorectal cancer’ (DCC) gene, which predicts a poor outcome for patients with colorectal carcinoma, can also serve as a prognostic factor in renal cell carcinoma (RCC).
PATIENTS AND METHODS
The expression of DCC was evaluated immunohistochemically in 94 paraffin-embedded tumour samples from patients with stage T1, T2, and T3 clear cell RCC. The mean follow-up was 52.3 months. The endpoints of the study were recurrence of disease and death from disease.
RESULTS
The under-expression of DCC protein was detected in 63% of patients who died from the disease and in 36% with no evidence of disease. DCC protein under-expression was detected in all patients with T1 tumours who died from the disease, in half the T2 tumours and in two-thirds of T3 tumours.
CONCLUSION
DCC protein under-expression correlated with more aggressive tumour behaviour and a greater risk of death from RCC. However, a larger cohort of patients should be assessed before drawing definitive conclusions.