Allopurinol provides long-term protection for experimentally induced testicular torsion in a rabbit model
Article first published online: 13 OCT 2005
Volume 96, Issue 7, pages 1147–1148, November 2005
How to Cite
Kehinde, E. O. (2005), Allopurinol provides long-term protection for experimentally induced testicular torsion in a rabbit model. BJU International, 96: 1147–1148. doi: 10.1111/j.1464-410X.2005.05924_5.x
- Issue published online: 13 OCT 2005
- Article first published online: 13 OCT 2005
We read with interest the comments of Prof. Bozlu on our paper . The facts of the matter are as follows:
Bozlu et al. (ref 3 in ) showed the long-term protective effects of 3-aminobenzamide on histological damage in a testicular torsion model published in April 2004. The first draft of our paper in the BJU Int was sent to the Editor in March 2004, when their paper had not been published. It was therefore impossible for us to cite their as yet unpublished paper!
The other paper by Bozlu et al. (ref 6 in ) reported the beneficial effect of 3-aminobenzamide in a torsion model lasting only 4 h and not 60 days, as they stated. Our paper was addressing long-term (3-month) protective effects of commonly used antioxidants.
The data shown in Table 2 of our paper are correct! In our original submission, the data shown in Table 2 were given in three different tables with footnotes added to avoid any confusion! In group C animals, the data shown in Table 2 for the long-term were derived as follows: the left testes were harvested after 60 min of ischaemia (no reperfusion), but the right testes of the animals were harvested after 24 h (short term) in one set of animals and at 3 months (long term) in another. In both sets of animals (short- or long-term), the data shown for the left testis were values obtained when the left testes were harvested after 60 min of ischaemia on day 0 of the experiments.
We indicated the scientific basis for choosing 3 months to assess long-term damage in our model. Bozlu et al. (reference 3 in ) provided no scientific basis for selecting 60 days as the time to assess long-term damage in their model.