Persistent detrusor overactivity after transurethral resection of the prostate is associated with reduced perfusion of the urinary bladder
Version of Record online: 22 JAN 2007
Volume 99, Issue 4, pages 831–835, April 2007
How to Cite
Mitterberger, M., Pallwein, L., Gradl, J., Frauscher, F., Neuwirt, H., Leunhartsberger, N., Strasser, H., Bartsch, G. and Pinggera, G.-M. (2007), Persistent detrusor overactivity after transurethral resection of the prostate is associated with reduced perfusion of the urinary bladder. BJU International, 99: 831–835. doi: 10.1111/j.1464-410X.2006.06735.x
- Issue online: 22 JAN 2007
- Version of Record online: 22 JAN 2007
- Accepted for publication 20 October 2006
- detrusor overactivity;
- benign prostatic hyperplasia;
- benign prostatic enlargement
In an interesting study, authors from Austria attempted to elucidate how often detrusor overactivity persists after TURP, and if perfusion of the lower urinary tract influences the outcome. They found that increased vascular resistance of the bladder vessels leads to reduced perfusion, and provide a possible explanation for the persistent symptoms.
In a multicentre, community-based randomized study conducted in the USA and UK, the transdermal oxybutynin system improved the quality of life in adults with overactive bladder.
The final paper in this section is from Turkey, presenting the long-term results of transurethral vaporisation using plasmakinetic energy.
To elucidate, in patients with benign prostatic hyperplasia (BPH), how often detrusor overactivity (DOA) is persistent after transurethral resection of the prostate (TURP) and if perfusion of the lower urinary tract influences postoperative outcomes.
PATIENTS AND METHODS
Fifty men with urodynamically confirmed DOA and bladder outlet obstruction due to BPH had a TURP. Before and 1 year after TURP the International Prostate Symptom Score (IPSS), quality of life (QoL) score, prostate-specific antigen (PSA) level and total prostatic volume (TPV) were evaluated. Also, the lower urinary tract was evaluated using pressure-flow studies and transrectal colour Doppler ultrasonography to assess the vascular resistive index (RI) as a variable of the perfusion of the lower urinary tract.
After TURP the IPSS, QoL score, PSA level and TPV decreased. Cystometric measurements showed that in 15 (30%) patients DOA was persistent after TURP. The mean (sd) maximum urinary flow rate increased from 9.20 (4.03) to 15.98 (4.62) mL/s and postvoiding residual urine volumes decreased from 109.38 (73.71) to 29.24 (45.00) mL. When men with persistent DOA (15 patients; group 1) were compared with those with no DOA after TURP (35; group 2) there was a statistically significantly higher RI of the bladder vessels in group 1, at 0.86 (0.068) than in group 2, at 0.68 ( 0.055) (P < 0.001).
Persistent DOA in men after TURP seems to be associated with increased vascular resistance of the bladder vessels with subsequent reduced perfusion and hypoxia.