Is the use of parasympathomimetics for treating an underactive urinary bladder evidence-based?
Article first published online: 16 JAN 2007
Volume 99, Issue 4, pages 749–752, April 2007
How to Cite
Barendrecht, M. M., Oelke, M., Laguna, M. P. and Michel, M. C. (2007), Is the use of parasympathomimetics for treating an underactive urinary bladder evidence-based?. BJU International, 99: 749–752. doi: 10.1111/j.1464-410X.2006.06742.x
- Issue published online: 16 JAN 2007
- Article first published online: 16 JAN 2007
- Accepted for publication 10 November 2006
- bladder underactivity;
- acute urinary retention;
An underactive urinary bladder (UUB), often occurring after surgery, can lead to urinary retention even in otherwise healthy people. We systematically reviewed published reports to determine whether the use of parasympathomimetic agents is warranted in patients with a UUB. Agents allegedly useful in treating UUB were identified from urology and pharmacology textbooks. A systematic search for randomized clinical trials in patients with UUB using these agents revealed 10 such studies. Controls typically received placebo or no treatment. While three studies reported statistically significant improvements relative to the control group, six did not and one even reported a significant worsening of symptoms. There was no evidence for differences between individual drugs, specific uses of such drugs, or in outcome measures. We conclude that the available studies do not support the use of parasympathomimetics for treating UUB, specifically when frequent and/or serious possible side-effects are taken into account.