Association of vitamin D receptor (Fok-I) polymorphism with the clinical presentation of calcium urolithiasis

Authors

  • Chia-Chu Liu,

    1. Department of Urology, Kaohsiung Medical University, Kaohsiung, Department of Pathology, Kaohsiung Medical University, Kaohsiung, and
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  • Chun-Hsiung Huang,

    1. Department of Urology, Kaohsiung Medical University, Kaohsiung, Department of Pathology, Kaohsiung Medical University, Kaohsiung, and
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  • Wen-Jeng Wu,

    1. Department of Urology, Kaohsiung Medical University, Kaohsiung, Department of Pathology, Kaohsiung Medical University, Kaohsiung, and
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  • Shu-Pin Huang,

    1. Department of Urology, Kaohsiung Medical University, Kaohsiung, Department of Pathology, Kaohsiung Medical University, Kaohsiung, and
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  • Yii-Her Chou,

    1. Department of Urology, Kaohsiung Medical University, Kaohsiung, Department of Pathology, Kaohsiung Medical University, Kaohsiung, and
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  • Ching-Chia Li,

    1. Department of Urology, Kaohsiung Medical University, Kaohsiung, Department of Pathology, Kaohsiung Medical University, Kaohsiung, and
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  • Chee-Yin Chai,

    1. Department of Urology, Kaohsiung Medical University, Kaohsiung, Department of Pathology, Kaohsiung Medical University, Kaohsiung, and
    2. Department of Pathology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, and
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  • Ming-Tsang Wu

    Corresponding author
    1. Graduate Institute of Occupational Safety and Health, Kaohsiung Medical University, Kaohsiung, and Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan,
    2. Family Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
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Ming-Tsang Wu, Department of Family Medicine, Kaohsiung Medical University Hospital, TzYou 1st Road, Kaohsiung 807, Taiwan.
e-mail: 960021@ms.kmuh.org.tw

Abstract

OBJECTIVE

To investigate the effect of the vitamin D receptor (VDR) FokI polymorphism on the clinical presentation of calcium urolithiasis, as a FokI polymorphism in the VDR gene was recently reported to be associated with calcium metabolism disorders.

PATIENTS, SUBJECTS AND METHODS

In all, 235 patients with calcium urolithiasis and 231 age- and sex-matched healthy controls were recruited from Kaohsiung Medical University Hospital between June 2003 and February 2005. Clinical information on the age at first onset, stone episodes, stone severity and presence of family history were collected from patients with stones. Any VDR FokI polymorphism was detected using polymerase chain reaction-based restriction analysis.

RESULTS

The frequency of VDR FokI genotypes between the patients and the healthy controls was not significantly different. However, among patients, those with the FF genotype had a significantly higher risk of having more stone episodes (adjusted odds ratio 2.15, 95% confidence interval 1.02–4.54, P = 0.044) and were younger at the first onset (3.23, 1.08–9.63, P = 0.036) than those with the ff genotype.

CONCLUSION

The VDR FokI polymorphism might be important in the clinical presentation of patients with calcium urolithiasis, especially for the frequency of stone episodes and age at first onset, although it is not associated with the formation of stones.

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