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Computer-aided ultrasonography (HistoScanning): a novel technology for locating and characterizing prostate cancer

  1. Johan Braeckman1,
  2. Philippe Autier1,
  3. Christian Garbar1,
  4. Miriam Pipeleers Marichal1,
  5. Cristina Soviany2,
  6. Rina Nir2,
  7. Dror Nir2,
  8. Dirk Michielsen1,
  9. Harry Bleiberg3,
  10. Lars Egevad1,
  11. Mark Emberton4

Article first published online: 8 OCT 2007

DOI: 10.1111/j.1464-410X.2007.07232.x

Issue

BJU International

BJU International

Volume 101, Issue 3, pages 293–298, February 2008

Additional Information

How to Cite

Braeckman, J., Autier, P., Garbar, C., Marichal, M. P., Soviany, C., Nir, R., Nir, D., Michielsen, D., Bleiberg, H., Egevad, L. and Emberton, M. (2008), Computer-aided ultrasonography (HistoScanning): a novel technology for locating and characterizing prostate cancer. BJU International, 101: 293–298. doi: 10.1111/j.1464-410X.2007.07232.x

Author Information

  1. 1

    UZ Brussel, Vrije Universiteit, Brussels, Belgium, International Agency for Research on Cancer, Lyon, France,

  2. 2

    Advanced Medical Diagnostics, Waterloo, Belgium,

  3. 3

    Unit of Epidemiology and Prevention, and Screening Clinic, Jules Bordet Institute, Brussels, and

  4. 4

    Division of Surgery and Interventional Science University College London, UK

*Johan Braeckman, Academic Hospital, UZ Brussel, Vrije Universiteit Brussel, Laarbeeklaan 101 (1090) Jette, Belgium. e-mail: johan.braeckman@uzbrussel.be

Publication History

  1. Issue published online: 8 OCT 2007
  2. Article first published online: 8 OCT 2007
  3. Accepted for publication 13 July 2007

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Keywords:

  • prostate cancer;
  • diagnostics;
  • detection;
  • prostate biopsy

OBJECTIVE

To assess the extent to which prostate HistoScanningTM (PHS), a new ultrasound-based technology that uses computer-aided analysis to quantify tissue disorganization induced by malignant processes, can identify and characterize foci of prostate cancer compared with step-sectioned radical prostatectomy (RP) specimens.

PATIENTS AND METHODS

Between September 2004 and February 2006, 29 men had PHS before their scheduled RP. A three-dimensional ultrasound raw-data file was acquired, and PHS analysed regions of interest (ROI) corresponding to tissue volumes of ≈ 0.04 mL. In 13 men the histology was examined on sections of the whole-mount prostate onto which a grid of 5 × 5 mm squares was applied. On a test set of 14 of the 29 patients, PHS analysis was used before knowing the histology results (blinded data), to predict the maximum tumour diameter, focality, laterality and extraprostatic extension (EPE).

RESULTS

Identification and characterization by PHS of the index tumour in the 14 patients in the test set correlated closely (r = 0.95, P < 0.001) with the reference test. The concordance in the attribution of multifocality (present/absent), unilateral/bilateral disease between PHS and histology was 100%. EPE as determined by PHS was attributed to all three pT3a pathological specimens in the blinded paired data. In the same set of data, EPE was attributed to one prostate cancer that on pathological inspection was deemed to be organ-confined (pT2b).

CONCLUSIONS

PHS has the potential to identify and characterize prostate cancer foci noninvasively. The precision appears to be sufficient to suggest that PHS might be useful as a triage test for men deemed to be at risk of prostate cancer and who wish to avoid prostate biopsy.

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