I read this article  with interest. The Veterans Administration Cooperative Urology Research Group (VACURG) reports of 1968 (I), 1978 (II), 1986 (III) concluded that: (i) diethylstilbestrol (DES) 1 mg/day was safe and effective; (ii) DES 1 mg was more effective than orchidectomy; and (iii) DES 1 mg plus orchidectomy was no better than DES 1 mg alone, as measured by bone scan, acid phosphatase and death. In all of these studies (>40 000 men over 30 years) hormone therapy was initiated immediately on diagnosis .
Scherr et al.[3,4] showed that DES 1 mg prevents the osteoporosis of androgen deprivation. Scherr and Pitts  reviewed the nonsteroidal effects of DES, e.g. those against osteoporosis, angiogenesis, mitosis, tubulin, decrease in cognitive function, atherosclerosis, hot flashes and asthenia. Pitts  reviewed previous reports and showed that immediate androgen deprivation without oestrogen deprivation using DES 1 mg was the only form of therapy to slow progression and prolong life of any prostate cancer therapy (surgery, radiation, orchidectomy or other chemotherapy).