R.P. is the BAUS Section of Oncology Representative. R.E and K.R.M are joint senior authors. Lists available on request for The UK Genetic Prostate Cancer Study Collaborators, Surrey, and British Association of Urological Surgeons Section of Oncology, London, UK.
Sexual activity and prostate cancer risk in men diagnosed at a younger age
Version of Record online: 11 NOV 2008
© 2008 THE AUTHORS. JOURNAL COMPILATION © 2008 BJU INTERNATIONAL
Volume 103, Issue 2, pages 178–185, January 2009
How to Cite
Dimitropoulou, P., Lophatananon, A., Easton, D., Pocock, R., Dearnaley, D. P., Guy, M., Edwards, S., O’Brien, L., Hall, A., Wilkinson, R., The UK Genetic Prostate Cancer Study Collaborators, British Association of Urological Surgeons Section of Oncology, Eeles, R. and Muir, K. R. (2009), Sexual activity and prostate cancer risk in men diagnosed at a younger age. BJU International, 103: 178–185. doi: 10.1111/j.1464-410X.2008.08030.x
- Issue online: 23 DEC 2008
- Version of Record online: 11 NOV 2008
- Accepted for publication 30 May 2008
- sexual activity;
- cancer risk;
To examine, in a case-control study, the association between the frequency of sexual activity (intercourse, masturbation, overall) and prostate cancer risk in younger men diagnosed at ≤60 years old.
PATIENTS, SUBJECTS AND METHODS
In all, 431 prostate cancer cases and 409 controls participated and provided information on their sexual activity. In particular, the frequencies of intercourse and masturbation during the participants’ different age decades (20s, 30s, 40s, 50s) were collected.
Whereas frequent overall sexual activity in younger life (20s) increased the disease risk, it appeared to be protective against the disease when older (50s). Alone, frequent masturbation activity was a marker for increased risk in the 20s and 30s but appeared to be associated with a decreased risk in the 50s, while intercourse activity alone was not associated with the disease.
These findings could imply different mechanisms by which sexual activity is involved in the aetiology of prostate cancer at different ages. Alternatively, there is a possibility of reverse causation in explaining part of the protective effect seen for men in their 50s.