Pilot study evaluating ureteric physiological changes with a novel ‘ribbon stent’ design using electromyographic and giant magnetoresistive sensors
Version of Record online: 25 NOV 2008
© 2008 THE AUTHORS. JOURNAL COMPILATION © 2008 BJU INTERNATIONAL
Volume 103, Issue 8, pages 1128–1131, April 2009
How to Cite
Natalin, R. A., Hruby, G. W., Okhunov, Z., Singh, H., Phillips, C. K., Humphrey, P. A., Gupta, M. and Landman, J. (2009), Pilot study evaluating ureteric physiological changes with a novel ‘ribbon stent’ design using electromyographic and giant magnetoresistive sensors. BJU International, 103: 1128–1131. doi: 10.1111/j.1464-410X.2008.08184.x
- Issue online: 26 MAR 2009
- Version of Record online: 25 NOV 2008
- Accepted for publication 12 August 2008
- ureteric physiology;
- ureteric stent;
To test a novel ‘ribbon stent’ (RS) design using an extraluminal bipolar electromyographic (EMG) and giant magnetoresistive (GMR) sensor system to characterize ureteric responses.
MATERIALS AND METHODS
In all, 11 female domestic pigs were divided into three groups to evaluate ureteric physiology: group 1 (two pigs) with an unstented ureter, group 2 (three) with a standard 6 F ureteric stent, and group 3 (six) with the RS. For all groups EMG/GMR evaluation was performed at baseline, immediately after stenting, and at 3 and 7 days after stenting. All pigs underwent standardized retrograde ureteropyelogram evaluation at these time points, and after the final evaluation the pigs were killed and the urinary tract was harvested for histopathological evaluation.
One stent in group 3 could not be deployed due to a problem with ureteric access. For groups 1, 2 and 3 the ureteric peristaltic activity was 109, 63, 72 events/h at baseline (P = 0.49); 61, 70, and 66 events/h immediately after stenting (P = 0.97); 66, 0, 8 events/h at 3 days after stenting (P = 0.002); and 61, 12, 0 events/h at 7 days after stenting, respectively (P = 0.049).
The RS was deployed easily and safely in the porcine model using a standard technique. As with a standard stent, there was significant ureteric dilation and decrease in peristalsis with the RS.