Neuroendocrine tumours of the urinary system and male genital organs: clinical significance

Authors

  • Roberta Mazzucchelli,

    1. Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy, Department of Pathology, Reina Sofia University Hospital and Faculty of Medicine, Cordoba, Spain,
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  • Doriana Morichetti,

    1. Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy, Department of Pathology, Reina Sofia University Hospital and Faculty of Medicine, Cordoba, Spain,
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  • Antonio Lopez-Beltran,

    1. Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy, Department of Pathology, Reina Sofia University Hospital and Faculty of Medicine, Cordoba, Spain,
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  • Liang Cheng,

    1. Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA, and
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  • Marina Scarpelli,

    1. Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy, Department of Pathology, Reina Sofia University Hospital and Faculty of Medicine, Cordoba, Spain,
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  • Ziya Kirkali,

    1. Department of Urology, School of Medicine, Dokuz Eylül University, Izmir, Turkey
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  • Rodolfo Montironi

    1. Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy, Department of Pathology, Reina Sofia University Hospital and Faculty of Medicine, Cordoba, Spain,
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Rodolfo Montironi, Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Via Conca 71, I-60126 Torrette, Ancona, Italy.
e-mail: r.montironi@univpm.it

Abstract

Two basic types of neuroendocrine (NE) tumours with diverse clinicopathological features and outcome are identified in the urinary system and male genital organs: carcinoid tumour and neuroendocrine carcinoma. Carcinoid, a rare tumour, occurs in the kidney, bladder, prostate and testis. It is morphologically, histochemically, immunohistochemically and ultrastructurally similar to its counterpart in other organs, such as lung or gastrointestinal tract. Metastases can be detected at the initial evaluation, although they have been reported up to several years after removal, emphasizing the need for a long-term follow-up. NE carcinoma occurs in the kidney, bladder and prostate, and includes small cell carcinoma (SCC) and large cell NE carcinoma (LCNEC), the latter being exceedingly rare. Both show the morphology and immunophenotype of NE carcinoma originating in other organs. Although the occurrence is rare, it is highly aggressive.

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