Evaluation of the Prostate Cancer Prevention Trial Risk calculator in a high-risk screening population
Article first published online: 25 AUG 2009
© 2009 THE AUTHORS. JOURNAL COMPILATION © 2009 BJU INTERNATIONAL
Volume 105, Issue 3, pages 334–337, February 2010
How to Cite
Kaplan, D. J., Boorjian, S. A., Ruth, K., Egleston, B. L., Chen, D. Y. T., Viterbo, R., Uzzo, R. G., Buyyounouski, M. K., Raysor, S. and Giri, V. N. (2010), Evaluation of the Prostate Cancer Prevention Trial Risk calculator in a high-risk screening population. BJU International, 105: 334–337. doi: 10.1111/j.1464-410X.2009.08793.x
- Issue published online: 14 JAN 2010
- Article first published online: 25 AUG 2009
- Accepted for publication 15 May 2009
- prostate cancer;
Study Type – Diagnostic (exploratory cohort) Level of Evidence 2b
To evaluate the Prostate Cancer Prevention Trial (PCPT) risk calculator in a screening cohort of young, racially diverse, high-risk men with a low baseline prostate-specific antigen (PSA) level and enrolled in the Prostate Cancer Risk Assessment Program (PRAP). The PCPT calculator provides an assessment of prostate cancer risk based on age, PSA level, race, previous biopsy, and family history.
PATIENTS AND METHODS
Eligibility for PRAP includes men aged 35–69 years who are African-American, have a family history of prostate cancer, or have a known BRCA1/2 mutation. PCPT risk scores were determined for PRAP participants, and were compared to observed prostate cancer rates.
In all, 624 participants were evaluated, including 382 (61.2%) African-American men and 242 (38.7%) men with a family history of prostate cancer; the median (range) age was 49.0 (34.0–69.0) years and the median PSA level 0.9 (0.1–27.2) ng/mL. The PCPT risk score correlated with prostate cancer diagnosis, as the median baseline risk score in patients diagnosed with prostate cancer was 31.3%, vs 14.2% in patients not diagnosed with prostate cancer (P < 0.001). The PCPT calculator similarly stratified the risk of diagnosis of Gleason score ≥7 disease, as the median risk score was 36.2% in patients diagnosed with Gleason ≥7 prostate cancer vs 15.2% in all other participants (P < 0.001).
The PCPT risk calculator score was found to stratify prostate cancer risk in a cohort of young, primarily African-American men with a low baseline PSA level. These results support further evaluation of this predictive tool for assessing the risk of prostate cancer in high-risk men.