Association of statin and nonsteroidal anti-inflammatory drug use with prostate cancer outcomes: results from CaPSURE
Article first published online: 13 AUG 2010
© 2010 THE AUTHORS. JOURNAL COMPILATION © 2010 BJU INTERNATIONAL
Volume 106, Issue 5, pages 627–632, September 2010
How to Cite
Katz, M. S., Carroll, P. R., Cowan, J. E., Chan, J. M. and D’Amico, A. V. (2010), Association of statin and nonsteroidal anti-inflammatory drug use with prostate cancer outcomes: results from CaPSURE. BJU International, 106: 627–632. doi: 10.1111/j.1464-410X.2010.09232.x
- Issue published online: 13 AUG 2010
- Article first published online: 13 AUG 2010
- Accepted for publication 27 November 2009
- prostate cancer;
- all-cause mortality;
Study Type – Prevalence (prospective cohort) Level of Evidence 1b
To determine whether 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) and nonsteroidal anti-inflammatory drugs (NSAIDs) are associated with the risk of prostate cancer and improved survival in men with prostate cancer.
PATIENTS AND METHODS
We retrospectively examined the association between NSAID and statin use among 7042 men who underwent radical prostatectomy (RP, 4611) or radiotherapy (RT, 2431) for prostate cancer between 1990 and 2003 identified in the Cancer of the Prostate Strategic Urologic Research Endeavor (CaPSURE), a primarily community-based national prostate cancer registry. We compared clinical and sociodemographic variables by statin and NSAID use, using chi-square tests and multinomial logistic regression. We examined associations between medications and comorbid illness with mortality using unadjusted and adjusted Cox proportional hazard models.
The median (range) follow-up from treatment was 4 (0–16) years. In multivariate survival analysis, statin ‘ever-use’ was associated with a reduced risk of all-cause mortality (ACM) after RP (hazard ratio, HR, 0.35, 95% confidence interval, CI, 0.21–0.58) and RT (0.59, 0.37–0.94). NSAID ever-use was also associated with a reduced risk of ACM after RP (HR 0.47, 95% CI 0.30–0.75) and RT (0.39, 0.25–0.59).
In a population of men with prostate cancer, statin and NSAID ever-use were associated with a reduced risk of ACM. Our study highlights the importance of multidisciplinary survivorship care for men with prostate cancer.