The interaction of body mass index and race in predicting biochemical failure after radical prostatectomy
Article first published online: 13 OCT 2010
© 2010 BJU INTERNATIONAL. NO CLAIM TO ORIGINAL US GOVERNMENTWORKS
Volume 107, Issue 11, pages 1741–1747, June 2011
How to Cite
Lee, D. J., Ritch, C., Desai, M., Benson, M. C. and McKiernan, J. M. (2011), The interaction of body mass index and race in predicting biochemical failure after radical prostatectomy. BJU International, 107: 1741–1747. doi: 10.1111/j.1464-410X.2010.09768.x
- Issue published online: 19 MAY 2011
- Article first published online: 13 OCT 2010
- Accepted for publication 17 June 2010
- prostate cancer;
- biochemical recurrence
Study Type – Therapy (case series) Level of Evidence 4
• To examine the interaction of body mass index (BMI) and race in predicting biochemical failure (BCF) after radical prostatectomy (RP). The relative contribution of BMI and race to BCF after RP has not been well characterized.
PATIENTS AND METHODS
• From 1988 to 2008, 969 white and black men underwent RP and BMI data were available. In all, 168 (17.3%) were black and 801 (82.7%) were white men.
• BCF was defined as a post-surgery PSA level ≥0.2 ng/mL on ≥2 measurements. Cox regression methods were used to model the relationship between race, BMI and BCF.
• The 969 men had a mean age of 59.8 ± 7.2 years. There was no significant difference in BMI between black and white men (P= 0.32).
• The 5-year disease-free survival for black obese men was the lowest at 48%, compared with non-obese black (73%), obese white (82%) and non-obese white men (83%, P < 0.001).
• BMI did not have a significant impact on BCF. In a multivariate analysis, black race remained an independent predictor of BCF [hazard ratio (HR) = 1.76, P= 0.01].
• BMI does not affect the risk of BCF in black men differently than white men (P value for interaction 0.93).
• Black race is an independent predictor of biochemical failure after adjusting for pathological factors. The impact of BMI on BCF did not vary among different races.
• These findings suggest that elevated BMI does not affect the BCF rates of black men more than in other races, and that other factors may influence the racial variability in disease-free survival and BCF risk.