The impact of hypertriglyceridemia on prostate cancer development in patients aged ≥60 years
Article first published online: 4 AUG 2011
© 2011 THE AUTHORS. BJU INTERNATIONAL © 2011 BJU INTERNATIONAL
Volume 109, Issue 4, pages 515–519, February 2012
How to Cite
Hayashi, N., Matsushima, M., Yamamoto, T., Sasaki, H., Takahashi, H. and Egawa, S. (2012), The impact of hypertriglyceridemia on prostate cancer development in patients aged ≥60 years. BJU International, 109: 515–519. doi: 10.1111/j.1464-410X.2011.10358.x
- Issue published online: 7 FEB 2012
- Article first published online: 4 AUG 2011
- Accepted for publication 15 March 2011
- Gleason score;
- prostate cancer;
Study Type – Aetiology (individual cohort)
Level of Evidence 2b
What's known on the subject? and What does the study add?
Patients aged ≥60 years with high TG levels may be move vulnerable to the development of prostate cancer with aggressive biology.
We urologists have to pay attention to select the treatment for patients aged ≥60 year with high TG levels.
- • To investigate the relationship between serum triglyceride (TG) levels and the incidence and characteristics of prostate cancer detected on biopsy.
PATIENTS AND METHODS
- • We evaluated data from consecutive patients who underwent prostatic biopsy. Data analysed included age, total serum prostate-specific antigen (PSA) level, prostatic volume, body mass index (BMI), TG levels, and cholesterol-lowering medications.
- • We analysed data from 905 patients, including 528 (58.3%) with positive biopsy findings.
- • Using 150 mg/dL as the threshold point of TG levels, multivariate analysis yielded an adjusted odds ratio (OR) reflecting the association of higher TG levels with prostate cancer diagnosis of 1.66 (95% confidence interval (CI) 1.21–2.29, P = 0.002).
- • Pearson correlation coefficient analysis including age, PSA level, prostatic volume, BMI and TG, showed TG level significantly correlated with BMI (r = 0.185, P < 0.001).
- • In the analysis by age intervals (≤59, 60–69, and ≥70 years), the association between high TG levels and positive biopsy findings was enhanced in the age groups 60–69 and ≥70 years (OR 2.10, 95% CI 1.31–3.37, P = 0.002 and OR 1.91, 95% CI 1.03–3.53, P = 0.039, respectively), but not in the group aged ≤59 years.
- • In patients aged ≥60 years, high TG levels were statistically significantly associated with a Gleason score of ≥8.
- • High TG levels correlated well with a higher incidence of prostate cancer, especially in patients aged ≥60 years.
- • High TG levels were also associated with a Gleason score of ≥8 in this age group.
- • Our results suggest that elderly patients with high TG levels may be more vulnerable to the development of prostate cancer with an aggressive biology.