Contemporary diagnosis and management of squamous cell carcinoma (SCC) of the penis


Samuel Deem, Department of Urology, Charleston Area Medical Center, 3100 MacCorkle Ave. S.E. Suite 602, Charleston, WV 25304, USA. e-mail:


What's known on the subject? and What does the study add?

Penile cancer is a rare malignancy with limited evidence to support most treatment recommendations. No randomised controlled trials have been published and few recommendations are available for guiding management. However, evidence-based guidelines are currently available through the European Association of Urology.

This review provides the reader with the most up-to-date information on diagnosis and management of all stages of squamous cell carcinoma of the penis. It provides a rapid review and study guide for this rare disease.

  • • To review the current literature available on squamous cell carcinoma (SCC) of the penis and provide a contemporary management algorithm for treatment based on the best evidence available.
  • • A complete review of the current English language literature was performed via PubMed and all available guidelines were reviewed.
  • • Large randomised controlled trials are lacking in penile SCC due to the fortunately rare occurrence of the disease.
  • • Treatment recommendations for the primary lesion, lymph nodes, and follow-up in this review are based on the best current available literature.
  • • Early diagnosis and aggressive organ-sparing treatment remains the mainstay of therapy for penile SCC.
  • • Variable institutional expertise currently makes treatment decisions difficult and unstandardised.
  • • A multidisciplinary approach should be used in attempt to improve outcomes in this mutilating disease.