Non-steroidal anti-inflammatory drug use and the risk of benign prostatic hyperplasia-related outcomes and nocturia in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial

Authors

  • Siobhan Sutcliffe,

    Corresponding author
    1. Division of Public Health Sciences and the Alvin J. Siteman Cancer Center, Department of Surgery
      Siobhan Sutcliffe, Division of Public Health Sciences and the Alvin J. Siteman Cancer Center, Department of Surgery, Washington University School of Medicine, 660 South Euclid Avenue, Box 8100, Room 5026, St Louis, MO 63110, USA. e-mail: sutcliffes@wudosis.wustl.edu
    Search for more papers by this author
  • Robert L. Grubb III,

    1. Division of Urologic Surgery and the Alvin J. Siteman Cancer Center, Washington University School of Medicine, St Louis, MO
    Search for more papers by this author
  • Elizabeth A. Platz,

    1. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, and the Brady Urological Institute and Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions, Baltimore
    Search for more papers by this author
  • Lawrence R. Ragard,

    1. Westat
    Search for more papers by this author
  • Thomas L. Riley,

    1. Information Management Services, Rockville
    Search for more papers by this author
  • Sally S. Kazin,

    1. Department of Mathematics, University of Georgia, Athens, GA
    Search for more papers by this author
  • Richard B. Hayes,

    1. Division of Epidemiology, Department of Environmental Medicine, New York University School of Medicine, New York City, NY, USA
    Search for more papers by this author
  • Ann W. Hsing,

    1. Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD
    Search for more papers by this author
  • Gerald L. Andriole,

    1. Division of Public Health Sciences and the Alvin J. Siteman Cancer Center, Department of Surgery
    Search for more papers by this author
  • on behalf of the Urologic Diseases in America Project


Siobhan Sutcliffe, Division of Public Health Sciences and the Alvin J. Siteman Cancer Center, Department of Surgery, Washington University School of Medicine, 660 South Euclid Avenue, Box 8100, Room 5026, St Louis, MO 63110, USA. e-mail: sutcliffes@wudosis.wustl.edu

Abstract

Study Type – Therapy (cohort)

Level of Evidence 4

What's known on the subject? and What does the study add?

Accumulating evidence suggests that inflammation may contribute to the development of BPH and LUTS. Therefore, it is plausible that anti-inflammatory agents, such as aspirin and other NSAIDs, may reduce the risk of BPH/LUTS, as was observed in a recent analysis of daily aspirin use and BPH/LUTS risk in the Olmsted County Study of Urinary Symptoms and Health Status in Men.

The present study, conducted in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial, found no association for recent aspirin or ibuprofen use with the risk of BPH/LUTS.

OBJECTIVE

  • • To investigate the relationship between non-steroidal anti-inflammatory drug (NSAID) use and the incidence of benign prostatic hyperplasia (BPH)-related outcomes and nocturia, a lower urinary tract symptom (LUTS) of BPH, in light of accumulating evidence suggesting a role for inflammation in BPH/LUTS development.

PATIENTS AND METHODS

  • • At baseline, participants in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial completed questions on recent, regular aspirin and ibuprofen use, BPH surgery, diagnosis of an enlarged prostate/BPH, and nocturia. Participants in the intervention arm also underwent a digital rectal examination (DRE), from which prostate dimensions were estimated, as well as a prostate-specific antigen (PSA) test. Only participants in the intervention arm without BPH/LUTS at baseline were included in the analysis (n= 4771).
  • • During follow-up, participants underwent annual DREs and PSA tests, provided annual information on finasteride use, and completed a supplemental questionnaire in 2006–2008 that included additional questions on diagnosis of an enlarged prostate/BPH and nocturia.
  • • Information collected was used to investigate regular aspirin or ibuprofen use in relation to the incidence of six BPH/LUTS definitions: diagnosis of an enlarged prostate/BPH, nocturia (waking two or more times per night to urinate), finasteride use, any self-reported BPH/LUTS, prostate enlargement (estimated prostate volume ≥30 mL on any follow-up DRE) and elevation in PSA level (>1.4 ng/mL on any follow-up PSA test).

RESULTS

  • • Generally, null results were observed for any recent, regular aspirin or ibuprofen use (risk ratio = 0.92–1.21, P= 0.043–0.91) and frequency of use (risk ratios for one category increase in NSAID use = 0.98–1.11, P-trends = 0.10–0.99) with incident BPH/LUTS.

CONCLUSION

  • • The findings obtained in the present study do not support a protective role for recent NSAID use in BPH/LUTS development.

Ancillary