Causes of diminished renal function in the affected kidney after partial nephrectomy
Article first published online: 14 MAR 2012
© 2012 BJU INTERNATIONAL
Volume 110, Issue 8b, pages E357–E361, October 2012
How to Cite
Tatsugami, K., Tanaka, S., Ohtsubo, S., Inokuchi, J., Yokomizo, A., Kuroiwa, K., Song, Y. H. and Naito, S. (2012), Causes of diminished renal function in the affected kidney after partial nephrectomy. BJU International, 110: E357–E361. doi: 10.1111/j.1464-410X.2012.011027.x
- Issue published online: 28 SEP 2012
- Article first published online: 14 MAR 2012
- Accepted for publication 10 November 2011
- partial nephrectomy;
- renal function;
- renal scintigraphy;
- renal tumour
Study Type – Prognosis (case series)
Level of Evidence 4
What's known on the subject? and What does the study add?
When partial nephrectomy is performed, renal vessels are clamped to avoid bleeding during tumour resection. Renal cooling during renal vessel clamping has the advantage of avoiding renal damage. We consider that the open approach is a choice for avoiding renal damage in patients with a solitary kidney or a risk of chronic kidney disease, if renal cooling cannot be performed in laparoscopic surgery.
The results obtained in the present study suggest that cold ischaemia has the advantage of the recovery of postoperative affected renal function. However, further evaluation for a long period after surgery is needed to evaluate the recovery of affected renal function.
- • To determine the cause of diminished renal function in the affected kidney after partial nephrectomy (PN) for renal tumour, we analyzed the relationship between operative data and postoperative recovery with respect to renal function.
PATIENTS AND METHODS
- • From May 2005 to December 2010, pre- and postoperative (1 week and 3 months after the procedure) renal function was evaluated by 99mTc- mercaptoacetyltriglycine clearance in 51 patients treated with open partial nephrectomy (OPN; n= 24) and laparoscopic partial nephrectomy (LPN; n= 27).
- • LPN was performed via retroperitoneal (RPLPN; n= 14) or transperitoneal (TPLPN; n= 13) routes.
- • Renal cooling was performed after renal hilar clamping in OPN and RPLPN, although not in TPLPN.
- • There were 10 patients (two in OPN, six in TPLPN, two in RPLPN) who had diminished renal function in the affected kidney from 1 week to 3 months after PN.
- • Warm ischaemia (versus cold ischaemia; P= 0.017) during renal hilar clamping resulted in diminished renal function.
- • Using multivariate analysis, renal cooling influenced postoperative diminished renal function (P= 0.008).
- • Successful preservation of renal function after PN depends on renal cooling during renal hilar clamping.
- • Cold ischaemia for avoiding renal damage is recommended if renal hilar clamping is necessary for tumour extraction.