Comparison of health-related quality-of-life outcomes for African-American and Caucasian-American men after radical prostatectomy
Article first published online: 19 MAR 2012
© 2012 BJU INTERNATIONAL
Volume 110, Issue 8, pages 1129–1133, October 2012
How to Cite
Lee, E. W., Marien, T., Laze, J., Agalliu, I. and Lepor, H. (2012), Comparison of health-related quality-of-life outcomes for African-American and Caucasian-American men after radical prostatectomy. BJU International, 110: 1129–1133. doi: 10.1111/j.1464-410X.2012.10951.x
- Issue published online: 28 SEP 2012
- Article first published online: 19 MAR 2012
- Accepted for publication 9 November 2011
- erectile dysfunction;
- prostate cancer;
- health-related quality of life
Study Type – Therapy (outcomes)
Level of Evidence 2c
What's known on the subject? and What does the study add?
In addition to a higher prevalence and biological aggressiveness of prostate cancer, African-Americans tend towards narrower pelvises than Caucasians resulting in a potentially more difficult surgical dissection doing radical prostatectomy and increased positive surgical margins. In this study, there was no difference in urinary or sexual HRQL or overall satisfaction between African-Americans and Caucasians 2 years after radical prostatectomy, suggesting that the potential technical challenges of a narrower pelvis do not translate into poorer outcomes for African-Americans.
- • To determine if any differences exist in postoperative health-related quality-of-life (HRQL) outcomes, e.g. erectile function and continence, after radical prostatectomy (RP) in African-American (AA) vs Caucasian-American (CA) men.
PATIENTS AND METHODS
- • Between October 2000 and July 2008, 1338 CA and 56 AA men underwent open RP by a single surgeon and signed informed consent to participate in a prospective longitudinal outcomes study.
- • The American Urological Association Symptom Score (AUA-SS) and University of California, Los Angeles, Prostate Cancer Index (UCLA-PCI) and a global assessment of satisfaction were self-administered at baseline and after RP 24 months.
- • Urinary, sexual, and satisfaction outcomes were compared at 24 months.
- • AA men had significantly higher rates of hypertension and diabetes.
- • There were no other significant baseline differences in age, co-morbidities, body mass index, phosphodiesterase type 5 inhibitor use, preoperative prostate-specific antigen level, AUA-SS, and UCLA-PCI scores.
- • There were no differences in the percentage of men undergoing nerve-sparing procedures, estimated blood loss, transfusion rates, or complication rates between the groups.
- • At 24 months after RP the mean UCLA-PCI urinary and sexual function and bother scores and global satisfaction scores were similar between the groups.
- • AA and CA men experience no significant differences in urinary and sexual HRQL or overall satisfaction after open RP when performed by a single experienced surgeon.