J.Y.J. and S.P. contributed equally to this study.
Association of common variations of 8q24 with the risk of prostate cancer in Koreans and a review of the Asian population
Article first published online: 15 MAY 2012
© 2012 BJU INTERNATIONAL
Volume 110, Issue 6b, pages E318–E325, September 2012
How to Cite
Joung, J. Y., Park, S., Yoon, H., Lee, S. J., Park, W. S., Seo, H. K., Chung, J., Kim, S.-Y., Hong, S.-H., Lee, Y.-S., Kim, J. and Lee, K. H. (2012), Association of common variations of 8q24 with the risk of prostate cancer in Koreans and a review of the Asian population. BJU International, 110: E318–E325. doi: 10.1111/j.1464-410X.2012.11211.x
- Issue published online: 24 AUG 2012
- Article first published online: 15 MAY 2012
- Accepted for publication 18 January 2012
- prostate cancer;
- single nucleotide polymorphisms;
What's known on the subject? and What does the study add?
The association between subjects with the genetic variation of 8q24 and the risk of development of prostate cancer in Korean men was found. As a result of haplotype analysis, [AGC] and [CTA] carriers showed a significant association with prostate cancer risk. This is clinically meaningful as an initial study on genetic susceptibility to prostate cancer in Korean men and the first report of 8q24 haplotypes in an Asian population.
- • To determine the association between genetic variation of 8q24 with prostate cancer risk in Korean men.
PATIENTS AND METHODS
- • With a hospital-based case-control study design, we enrolled 194 patients with prostate cancer and 169 healthy controls from visitors for cancer screening.
- • DNA samples were obtained from peripheral blood for the analysis of single nucleotide polymorphisms (SNPs). Three SNPs of 8q24, including rs16901979, rs6983267, and rs1447295, were genotyped on cases and controls.
- • The subjects with the rs1447295 CA or AA genotype had a higher risk of prostate cancer than the CC genotype.
- • The A allele at SNP rs1447295 was associated with the incidence of prostate cancer.
- • The rs16901979 CA genotype carriers had a higher risk of prostate cancer than the CC genotype.
- • Individuals with the [AGC] and [CTA] haplotypes had a significantly increased risk of prostate cancer compared with the [CTC] haplotype ([AGC] with adjusted odds ratio [OR] 1.79; 95% confidence interval [CI] 1.09–2.96; P= 0.022; [CTA] with adjusted OR 5.17; 95% CI 2.40–11.15; P < 0.001).
- • The genetic variation of 8q24 is associated with the risk of prostate cancer in Korean men.
- • Individuals with the [AGC] and [CTA] haplotypes had a significant association with prostate cancer risk.