A review of expression profiling of circulating microRNAs in men with prostate cancer


Correspondence: Brian D. Kelly, Department of Surgery, National University of Ireland Galway, Clinical Science Institute, Newcastle Road, Galway, Ireland.

e-mail: drbriankelly@hotmail.com


What's known on the subject? and What does the study add?

MicroRNAs are small, single-stranded RNA molecules that are stable in the circulation. These molecules have been identified as potential circulating biomarkers for several malignancies.

In this review we provide a comprehensive overview of the publications that have identified dysregulated microRNAs in the circulation of men with prostate cancer.

  • MicroRNAs (miRNAs) are small non-coding RNAs that are involved in gene regulation and expression. These molecules have been implicated in the pathogenesis of several malignancies.
  • MiRNAs have the potential to be both a tissue- and blood-based biomarker for cancer diagnosis, classification, prognosis and response to treatment.
  • The levels of dysregulated miRNAs in the circulation of individuals make miRNAs an ideal biomarker for the detection of prostate cancer.
  • The present study provides a comprehensive review of the expression profiling of miRNAs in the circulation of men with prostate cancer.
  • Further research is necessary to identify if circulating miRNAs have the potential to be a biomarker for prostate cancer in clinical practice.