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Keywords:

  • transrectal sonoelastography;
  • TRSE;
  • prostate cancer;
  • PCa

Study Type – Diagnostic (exploratory cohort)

Level of Evidence 3a

What's known on the subject? and What does the study add?

The accuracy of transrectal sonoelastography (TRSE) in the detection of prostate cancer is variable, with a sensitivity ranging from 51.1 to 91.7% and specificity ranging from 62.2 to 86.8%.

This is the first meta-analysis to assess the overall accuracy of TRSE in the detection of prostate cancer.

OBJECTIVE

  • • 
    To assess the overall accuracy of transrectal sonoelastography (TRSE) targeted biopsy in the diagnosis of patients suspected of having prostate cancer (PCa).

METHODS

  • • 
    A systematic search of electronic databases, including PubMed, Embase and The Cochrane Library, and manual bibliography searches were performed.
  • • 
    All relevant studies assessing the diagnostic accuracy of TRSE in PCa detection were included in our meta-analysis.
  • • 
    The data were pooled and sensitivity, specificity, area under the curve (AUC), positive likelihood ratio (LR) and negative LR were calculated.

RESULTS

  • • 
    Pooled patient data analysis: the pooled (95% confidential intervals [95% CI]) sensitivity of TRSE targeted biopsy in patients suspected of having PCa was 62 (55–68) %; specificity was 79% (74–84%); AUC was 0.7696; positive LR was 2.92 (2.28–3.74); and negative LR was 0.49 (0.41–0.59).
  • • 
    Pooled core data analysis: pooled (95% CI) sensitivity, specificity, positive LR and negative LR were 34% (30–38%), 93% (91–95%), 5.07 (3.91–6.57) and 0.71 (0.66–0.75), respectively.

CONCLUSION

  • • 
    Transrectal sonoelastography is a promising technique in PCa detection and can be considered to be a valuable supplemental method to systemic biopsy.