Lower Urinary Tract
Prognostic factors for recent-onset interstitial cystitis/painful bladder syndrome
Article first published online: 9 AUG 2012
© 2012 BJU INTERNATIONAL
Volume 111, Issue 3b, pages E92–E97, March 2013
How to Cite
Warren, J. W., Clauw, D. J. and Langenberg, P. (2013), Prognostic factors for recent-onset interstitial cystitis/painful bladder syndrome. BJU International, 111: E92–E97. doi: 10.1111/j.1464-410X.2012.11422.x
- Issue published online: 1 MAR 2013
- Article first published online: 9 AUG 2012
- Accepted for publication 10 May 2012
- interstitial cystitis;
- painful bladder syndrome;
- prognostic factors;
- chronic fatigue syndrome
Study Type – Prognosis (case series)
Level of Evidence 4
What's known on the subject? and What does the study add?
Interstitial cystitis/painful bladder syndrome (IC/PBS) comprises pain perceived to be from the bladder, urinary urgency and frequency, and nocturia. As diagnosed at present, it is primarily identified in adult women. It is a chronic disease yet its natural history has not been well studied.
In a prospective study of 304 incident female IC/PBS cases followed for a median of 33 months after onset, women with baseline chronic fatigue syndrome had a worse prognosis for IC/PBS. Mild IC/PBS at baseline was the only variable that was directly associated with a good prognosis.
- • To identify baseline variables that predict the prognosis of interstitial cystitis/painful bladder syndrome (IC/PBS) in women seeking medical care for recent onset of this syndrome.
SUBJECTS AND METHODS
- • In a prospective study of women with incident IC/PBS (≤12 months of symptoms), we contacted patients at intervals and asked standardized questions about IC/PBS symptoms in the previous week.
- • Logistic regression analyses assessed baseline variables as predictors of mild vs more severe IC/PBS at the last follow-up.
- • Median length of follow-up was 33 months after onset of IC/PBS; 304 (97%) patients had at least one follow-up assessment.
- • Mild IC/PBS at baseline was the only variable that was directly associated with a mild IC/PBS endpoint.
- • Conversely, a history of chronic fatigue syndrome (CFS) was inversely associated with a mild endpoint of IC/PBS (i.e. individuals with CFS had a worse prognosis for their IC/PBS symptoms).
- • At a median of nearly 3 years after onset, baseline mild IC/PBS was directly associated with a milder disease severity.
- • Baseline co-morbid CFS was associated with more severe disease.
- • Whether CFS was uniquely associated or represented several co-morbid non-bladder syndromes (NBSs) could not be determined.