Get access

Diabetes mellitus as a risk factor for primary open-angle glaucoma: a meta-analysis

Authors

  • S. Bonovas,

    Corresponding author
    1. Department of General Practice, General Hospital of Athens ‘G. Gennimatas’, Athens, and
      Stefanos Bonovas, Asklipiou 17–19, GR-15354, Glika Nera, Greece. E-mail: sbonovas@med.uoa.gr
    Search for more papers by this author
  • V. Peponis,

    1. Department of General Practice, General Hospital of Athens ‘G. Gennimatas’, Athens, and
    2. Department of Ophthalmology, General Hospital of Piraeus ‘Tzaneion’, Piraeus, Greece
    Search for more papers by this author
  • K. Filioussi

    1. Department of General Practice, General Hospital of Athens ‘G. Gennimatas’, Athens, and
    Search for more papers by this author

Stefanos Bonovas, Asklipiou 17–19, GR-15354, Glika Nera, Greece. E-mail: sbonovas@med.uoa.gr

Abstract

Aim  The association of diabetes mellitus with primary open-angle glaucoma has been controversial. The study aimed to examine the strength of this association through a detailed meta-analysis of studies published in peer-reviewed journals.

Methods  A comprehensive search for articles published through 2002 was performed and data were abstracted. Prior to meta-analysis, all studies were evaluated for publication bias and heterogeneity. Pooled odds ratio (OR) was calculated using the random and the fixed-effects model.

Results  Twelve studies published between 1987 and 2001 were included (five case–control studies and seven cross-sectional studies). Significant heterogeneity among the studies was detected (P = 0.023). No evidence of publication bias was found (P = 0.37). The association of diabetes mellitus with primary open-angle glaucoma was statistically significant assuming either a random effects [OR = 1.50, 95% confidence interval (CI) 1.16, 1.93], or a fixed-effects model (OR = 1.27, 95% CI 1.10, 1.45).

Conclusions  Our meta-analysis results suggest that diabetic patients are at significantly increased risk of developing primary open-angle glaucoma. Clinicians should be aware of this possibility.

Diabet. Med. (2004)

Get access to the full text of this article

Ancillary