A prospective study of Type 2 diabetes and depressive symptoms in the elderly: The Rancho Bernardo Study
Article first published online: 29 JUL 2004
Volume 21, Issue 11, pages 1185–1191, November 2004
How to Cite
Palinkas, L. A., Lee, P. P. and Barrett-Connor, E. (2004), A prospective study of Type 2 diabetes and depressive symptoms in the elderly: The Rancho Bernardo Study. Diabetic Medicine, 21: 1185–1191. doi: 10.1111/j.1464-5491.2004.01315.x
- Issue published online: 20 OCT 2004
- Article first published online: 29 JUL 2004
- Accepted 8 December 2003
- depressive symptoms;
- older adults;
- prospective study;
- Type 2 diabetes
Aims The association between Type 2 diabetes and depressive symptoms was examined prospectively to assess possible causal relationships between the two diseases.
Methods A cohort of 971 men and women aged 50 and older from the adult population of Rancho Bernardo, California had an oral glucose tolerance test and completed the Beck Depression Inventory (BDI) at two clinic visits, 1984–87 and 1992–96.
Results Depressive symptoms at baseline were associated with higher follow-up levels of non-fasting plasma glucose (P = 0.001) and an increased risk of developing Type 2 diabetes [odds ratio (OR) = 2.50; 95% confidence interval (CI) = 1.29–4.87], independent of sex, age, exercise and body mass index. Conversely, baseline non-fasting plasma glucose was not significantly associated with follow-up depressive symptoms and Type 2 diabetes at baseline was not significantly associated with the onset of BDI scores ≥ 11 by the second visit (OR = 0.73; 95% CI = 0.41–1.30).
Conclusions Depressed mood is more likely to be a risk factor for Type 2 diabetes in older adults than the reverse.