Short-term effects of severe dietary carbohydrate-restriction advice in Type 2 diabetes—a randomized controlled trial

  1. M. E. Daly1,*,
  2. R. Paisey2,
  3. R. Paisey2,
  4. B. A. Millward3,4,
  5. C. Eccles3,
  6. K. Williams2,
  7. S. Hammersley1,
  8. K. M. MacLeod1,4,
  9. T. J. Gale1,4

Article first published online: 1 SEP 2005

DOI: 10.1111/j.1464-5491.2005.01760.x

Issue

Diabetic Medicine

Diabetic Medicine

Volume 23, Issue 1, pages 15–20, January 2006

Additional Information

How to Cite

Daly, M. E., Paisey, R., Paisey, R., Millward, B. A., Eccles, C., Williams, K., Hammersley, S., MacLeod, K. M. and Gale, T. J. (2006), Short-term effects of severe dietary carbohydrate-restriction advice in Type 2 diabetes—a randomized controlled trial. Diabetic Medicine, 23: 15–20. doi: 10.1111/j.1464-5491.2005.01760.x

Author Information

  1. 1

    Diabetes and Vascular Health Centre, Royal Devon and Exeter NHS Trust, Exeter,

  2. 2

    Torbay Hospital, Torquay,

  3. 3

    Derriford Hospital, Plymouth and

  4. 4

    Peninsula Medical School, Universities of Plymouth and Exeter, UK

*Correspondence: Mark Daly, Diabetes and Vascular Health Centre, Royal Devon and Exeter NHS Trust, Barrack Road, Exeter EX2 5DW, UK. E-mail: m.e.daly@exeter.ac.uk

Publication History

  1. Issue published online: 1 SEP 2005
  2. Article first published online: 1 SEP 2005
  3. Accepted 16 March 2005

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Keywords:

  • dietary carbohydrate;
  • weight loss;
  • Type 2 diabetes;
  • obesity;
  • lipids

Abstract

Objective  This study sought to examine the effects of a 3-month programme of dietary advice to restrict carbohydrate intake compared with reduced-portion, low-fat advice in obese subjects with poorly controlled Type 2 diabetes.

Research design and methods  One hundred and two patients with Type 2 diabetes were recruited across three centres and randomly allocated to receive group education and individual dietary advice. Weight, glycaemic control, lipids and blood pressure were assessed at baseline and 3 months. Dietary quality was assessed at the end of study.

Results  Weight loss was greater in the low-carbohydrate (LC) group (−3.55 ± 0.63, mean ± sem) vs. −0.92 ± 0.40 kg, P = 0.001) and cholesterol : high-density lipoprotein (HDL) ratio improved (−0.48 ± 0.11 vs. −0.10 ± 0.10, P = 0.01). However, relative saturated fat intake was greater (13.9 ± 0.71 vs. 11.0 ± 0.47% of dietary intake, P < 0.001), although absolute intakes were moderate.

Conclusions  Carbohydrate restriction was an effective method of achieving short-term weight loss compared with standard advice, but this was at the expense of an increase in relative saturated fat intake.

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