Circulating adipocytokines in non-diabetic and Type 1 diabetic children: relationship to insulin therapy, glycaemic control and pubertal development

  1. F. Celi,
  2. V. Bini,
  3. F. Papi,
  4. E. Santilli,
  5. M. S. Castellani,
  6. A. Ferretti,
  7. M. Mencacci,
  8. M. G. Berioli,
  9. G. De Giorgi,
  10. A. Falorni

Article first published online: 26 MAY 2006

DOI: 10.1111/j.1464-5491.2006.01823.x

Issue

Diabetic Medicine

Diabetic Medicine

Volume 23, Issue 6, pages 660–665, June 2006

Additional Information

How to Cite

Celi, F., Bini, V., Papi, F., Santilli, E., Castellani, M. S., Ferretti, A., Mencacci, M., Berioli, M. G., De Giorgi, G. and Falorni, A. (2006), Circulating adipocytokines in non-diabetic and Type 1 diabetic children: relationship to insulin therapy, glycaemic control and pubertal development. Diabetic Medicine, 23: 660–665. doi: 10.1111/j.1464-5491.2006.01823.x

Author Information

  1. Department of Medical-Surgical Specialties and Public Health, Section of Paediatrics, University of Perugia, Perugia, Italy

* Adriano Falorni MD, Department of Medical-Surgical Specialties and Public Health, Section of Paediatrics, University of Perugia, Azienda Ospedaliera Policlinico Monteluce, Via Brunamonti, 06100 Perugia, Italy. E-mail: adrifal@unipg.it

Publication History

  1. Issue published online: 26 MAY 2006
  2. Article first published online: 26 MAY 2006
  3. Accepted 9 September 2005

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Keywords:

  • adiponectin;
  • leptin;
  • resistin;
  • TNF-α;
  • Type 1 diabetic children

Abstract

Aim  To determine the influence of Type 1 diabetes mellitus on circulating adipocytokines in children.

Methods  The circulating concentrations of leptin, adiponectin, resistin and tumour necrosis factor (TNF)-α were measured in 91 children, aged 11.1 ± 2.7 years, with Type 1 diabetes mellitus (T1DM). Ninety-one healthy children were selected as control subjects.

Results  Body mass index-adjusted leptin concentrations were higher in the pubertal diabetic children compared with the control children. There was a significant positive correlation between leptin and daily insulin dose in the diabetic group. Circulating adiponectin concentrations were higher in the prepubertal diabetic children and were positively associated with HbA1c. Resistin concentrations were lower in the prepubertal non-diabetic subjects compared with the pubertal non-diabetic children, whose values were higher than those of the diabetic children. TNF-α concentrations were similar in non-diabetic and diabetic children.

Conclusions  Circulating concentrations of adipocytokines are abnormal in Type 1 diabetic children, although the direction of change differs by cytokine. Pubertal development, in addition to insulin treatment and glycaemic control, also influences the concentrations.

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