Studies of associations between the Arg389Gly polymorphism of the β1-adrenergic receptor gene (ADRB1) and hypertension and obesity in 7677 Danish white subjects

  1. A. P. Gjesing1,
  2. G. Andersen1,
  3. A. Albrechtsen1,
  4. C. Glümer1,2,
  5. K. Borch-Johnsen1,2,3,
  6. T. Jørgensen2,
  7. T. Hansen1,
  8. O. Pedersen1,3

Article first published online: 28 FEB 2007

DOI: 10.1111/j.1464-5491.2006.02031.x

Issue

Diabetic Medicine

Diabetic Medicine

Volume 24, Issue 4, pages 392–397, April 2007

Additional Information

How to Cite

Gjesing, A. P., Andersen, G., Albrechtsen, A., Glümer, C., Borch-Johnsen, K., Jørgensen, T., Hansen, T. and Pedersen, O. (2007), Studies of associations between the Arg389Gly polymorphism of the β1-adrenergic receptor gene (ADRB1) and hypertension and obesity in 7677 Danish white subjects. Diabetic Medicine, 24: 392–397. doi: 10.1111/j.1464-5491.2006.02031.x

Author Information

  1. 1

    Steno Diabetes Center, Gentofte,

  2. 2

    Research Centre for Prevention and Health, Glostrup University Hospital, Glostrup and

  3. 3

    Faculty of Health Science, University of Aarhus, Aarhus, Denmark

* : Anette P. Gjesing MSc, Steno Diabetes Center, Niels Steensens Vej 2, NSH2.16, DK-2820 Gentofte, Denmark. E-mail: apri@steno.dk

Publication History

  1. Issue published online: 28 FEB 2007
  2. Article first published online: 28 FEB 2007
  3. Accepted 14 August 2006

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Keywords:

  • adrenergic receptor;
  • epidemiology;
  • genetics;
  • hypertension;
  • obesity

Abstract

Aims  Activation of the β1-adrenergic receptor (ADRB1) causes increased lipolysis in adipose tissue and enhances cardiac output. Analysis of the association of the functional ADRB1 Arg389Gly variant with obesity and hypertension has given ambiguous results. To clarify the potential impact of this variant on obesity and hypertension in the general population, we examined the Arg389Gly variant in a relatively large-scale population-based study.

Methods  Case-control studies and quantitative trait analyses were carried out in 7677 Danish Caucasians who were genotyped for the Arg389Gly variant (dbSNP rs1801253) using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.

Results  A weak association between the Gly allele of the Arg389Gly variant and obesity was observed when comparing cases (n = 1540) defined as body mass index (BMI) > 30 kg/m2 with control subjects (n = 6108) defined as BMI ≤ 30 kg/m2 for both allele frequencies (P = 0.05) and genotype distribution (P = 0.05). Case-control studies (cases n = 2518; control n = 3981) examining the effect on hypertension showed no association with allele frequencies (P = 0.3) or genotype distribution (P = 0.5); however, in the quantitative trait analyses, individuals carrying the Gly allele had slightly but significantly lower diastolic (Arg/Arg = 81.9 mmHg vs. Gly-allele carriers = 81.5 mmHg) and systolic (Arg/Arg = 129.4 mmHg vs. Gly-allele carriers = 128.8 mmHg) blood pressure as well as a lower mean arterial blood pressure.

Conclusion  Our results suggest that the Arg389Gly polymorphism does not have any clinically important impact on the pathogenesis of obesity in Danish white subjects. Furthermore, despite the observed minor influence on blood pressure, this variant is most likely not to be a major contributor to the development of hypertension.

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