Perinatal risk factors for childhood Type 1 diabetes in Western Australia—a population-based study (1980–2002)
Article first published online: 26 APR 2007
Volume 24, Issue 5, pages 564–570, May 2007
How to Cite
Haynes, A., Bower, C., Bulsara, M. K., Finn, J., Jones, T. W. and Davis, E. A. (2007), Perinatal risk factors for childhood Type 1 diabetes in Western Australia—a population-based study (1980–2002). Diabetic Medicine, 24: 564–570. doi: 10.1111/j.1464-5491.2007.02149.x
- Issue published online: 26 APR 2007
- Article first published online: 26 APR 2007
- Accepted 21 December 2006
- birth order;
- birth weight;
- gestational age;
- maternal age;
- Type 1 diabetes
Aims To investigate perinatal risk factors for childhood Type 1 diabetes in Western Australia, using a complete population-based cohort.
Methods Children born between 1980 and 2002 and diagnosed with Type 1 diabetes aged < 15 years (n = 940) up to 31 December 2003 were identified using a prospective population-based diabetes register with a case ascertainment rate of 99.8%. Perinatal data were obtained for all live births in Western Australia from 1980 to 2002 (n = 558 633) and record linkage performed to identify the records of cases.
Results The incidence of Type 1 diabetes increased by 13% for each 5-year increase in maternal age [adjusted incidence rate ratio (IRR) 1.13, 95% confidence interval (CI) 1.05, 1.21], by 13% for every 500-g increase in birth weight (adjusted IRR 1.13, 95% CI 1.04, 1.23). The incidence decreased with increasing birth order (adjusted IRR 0.89, 95% CI 0.82, 0.96) and increasing gestational age (adjusted IRR 0.84, 95% CI 0.77, 0.93). A higher incidence of Type 1 diabetes was associated with an urban vs. non-urban maternal address at the time of birth (adjusted IRR 1.38, 95% CI 1.18, 1.63), but no association was found with socio-economic status of the area.
Conclusions A higher incidence of Type 1 diabetes was associated with increasing maternal age, higher birth weight, lower gestational age, lower birth order and urban place of residence at the time of birth.