Evidence for distinct effects of GH and IGF-I in the metabolic syndrome

  1. P. Maison1,2,
  2. B. Balkau3,
  3. J.-C. Souberbielle4,
  4. P. Cunin2,
  5. S. Vol5,
  6. I. Macquin-Mavier1,
  7. E. Eschwège3,
  8. the D. E. S. I. R. Study Group1

Article first published online: 29 MAY 2007

DOI: 10.1111/j.1464-5491.2007.02195.x

Issue

Diabetic Medicine

Diabetic Medicine

Volume 24, Issue 9, pages 1012–1018, September 2007

Additional Information

How to Cite

Maison, P., Balkau, B., Souberbielle, J.-C., Cunin, P., Vol, S., Macquin-Mavier, I., Eschwège, E. and the D. E. S. I. R. Study Group (2007), Evidence for distinct effects of GH and IGF-I in the metabolic syndrome. Diabetic Medicine, 24: 1012–1018. doi: 10.1111/j.1464-5491.2007.02195.x

Author Information

  1. 1

    Service de Pharmacologie Clinique,

  2. 2

    Unité de Recherche Clinique, AP-HP, Hôpital Henri Mondor, Université Paris XII, Créteil,

  3. 3

    INSERM U780-IFR69, Villejuif,

  4. 4

    Service d’Explorations Fonctionnelles, Hôpital Necker—Enfants Malades, Paris and

  5. 5

    IRSA, La Riche, France

* : Dr P. Maison, Service de Pharmacologie Clinique, Hôpital Henri Mondor, 94010 Créteil, France. E-mail: patrick.maison@hmn.aphp.fr

Publication History

  1. Issue published online: 29 MAY 2007
  2. Article first published online: 29 MAY 2007
  3. Accepted 31 January 2007

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Keywords:

  • diabetes;
  • growth hormone;
  • insulin growth factor I;
  • metabolic syndrome;
  • somatotropic axis

Abstract

Aims  The metabolic syndrome is a cluster of cardiovascular risk factors which include central obesity, dyslipidaemia, glucose intolerance and hypertension. These risk factors are common in patients with growth hormone (GH) deficiency, suggesting a role for the somatotropic axis in the development of metabolic syndrome.

Methods  We used factor analysis to investigate the relationships linking serum levels of GH and insulin-like growth factor I (IGF-I) to metabolic syndrome variables (high-density lipoprotein cholesterol, triglycerides, fasting glucose, blood pressure and waist circumference). We studied 359 men and 388 women from the Data from an Epidemiological Study on the Insulin Resistance syndrome (DESIR). Their age range was 30–64 years.

Results  Three independent latent factors explained 61% of the total variance in women and four factors explained 73% in men. In both men and women, IGF-I showed a strong positive correlation with the lipid factor and a negative correlation with the obesity/glucose factor. In women, GH showed a strong negative correlation with the obesity/glucose factor but not the lipid factor. In men, GH was unrelated to the lipid and obesity/glucose factors. The blood pressure factor was not related to GH or IGF-I. In contrast with IGF-I, GH was significantly lower in women with metabolic syndrome (1575 ± 449 pg/ml) than in the other women (2121 ± 520 pg/ml, P = 0.002). No significant difference was observed in men for GH or IGF-I.

Conclusion  Our results support a link between the somatotropic axis and several features of the metabolic syndrome, and suggest distinct effects of GH and IGF-I on these parameters.

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