Liraglutide, a once-daily human GLP-1 analogue, improves pancreatic B-cell function and arginine-stimulated insulin secretion during hyperglycaemia in patients with Type 2 diabetes mellitus
Article first published online: 15 JAN 2008
© 2008 The Authors.
Volume 25, Issue 2, pages 152–156, February 2008
How to Cite
Vilsbøll, T., Brock, B., Perrild, H., Levin, K., Lervang, H.-H., Kølendorf, K., Krarup, T., Schmitz, O., Zdravkovic, M., Le-Thi, T. and Madsbad, S. (2008), Liraglutide, a once-daily human GLP-1 analogue, improves pancreatic B-cell function and arginine-stimulated insulin secretion during hyperglycaemia in patients with Type 2 diabetes mellitus. Diabetic Medicine, 25: 152–156. doi: 10.1111/j.1464-5491.2007.02333.x
- Issue published online: 21 JAN 2008
- Article first published online: 15 JAN 2008
- Accepted 2 September 2007
- B-cell function;
- clinical trial;
- glucagon-like peptide-1;
- insulin secretion;
Aims To assess the effect of liraglutide, a once-daily human glucagon-like peptide-1 analogue on pancreatic B-cell function.
Methods Patients with Type 2 diabetes (n = 39) were randomized to treatment with 0.65, 1.25 or 1.9 mg/day liraglutide or placebo for 14 weeks. First- and second-phase insulin release were measured by means of the insulin-modified frequently sampled intravenous glucose tolerance test. Arginine-stimulated insulin secretion was measured during a hyperglycaemic clamp (20 mmol/l). Glucose effectiveness and insulin sensitivity were estimated by means of the insulin-modified frequently sampled intravenous glucose tolerance test.
Results The two highest doses of liraglutide (1.25 and 1.9 mg/day) significantly increased first-phase insulin secretion by 118 and 103%, respectively (P < 0.05). Second-phase insulin secretion was significantly increased only in the 1.25 mg/day group vs. placebo. Arginine-stimulated insulin secretion increased significantly at the two highest dose levels vs. placebo by 114 and 94%, respectively (P < 0.05). There was no significant treatment effect on glucose effectiveness or insulin sensitivity.
Conclusions Fourteen weeks of treatment with liraglutide showed improvements in first- and second-phase insulin secretion, together with improvements in arginine-stimulated insulin secretion during hyperglycaemia.