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First trimester serum neutrophil gelatinase-associated lipocalin in gestational diabetes
Article first published online: 18 AUG 2009
DOI: 10.1111/j.1464-5491.2009.02830.x
© 2009 The Authors. Journal compilation © 2009 Diabetes UK
Additional Information
How to Cite
D’Anna, R., Baviera, G., Corrado, F., Giordano, D., Recupero, S. and Di Benedetto, A. (2009), First trimester serum neutrophil gelatinase-associated lipocalin in gestational diabetes. Diabetic Medicine, 26: 1293–1295. doi: 10.1111/j.1464-5491.2009.02830.x
Publication History
- Issue published online: 24 NOV 2009
- Article first published online: 18 AUG 2009
- Accepted 8 August 2009
- Abstract
- Article
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Keywords:
- gestational diabetes;
- lipocalin;
- neutrophil gelatinase-associated lipocalin
Abstract
Aims Neutrophil gelatinase-associated lipocalin (NGAL) is highly expressed in damaged epithelia, during inflammation and cardiovascular disease. Soluble NGAL was measured in women who subsequently developed gestational diabetes.
Methods From a cohort of 908 pregnant outpatients who participated in a screening programme for Down’s syndrome at 9–12 weeks of gestation, we considered all 41 women with a singleton pregnancy, who developed gestational diabetes in the previous 12 months, and a control group of 82 normal pregnancies. Circulating NGAL and insulin resistance by homeostasis model assessment ratio (HOMA-IR) were determined in the first trimester.
Results Median serum NGAL concentrations were higher in the gestational diabetes group [51.3 ng/ml (39.8–66.1 ng/ml)] compared with the control group [17.8 ng/ml (15.5–20.9 ng/ml)] (P < 0.001) and positively correlated with HOMA-IR (P < 0.001).
Conclusions In the first trimester, circulating NGAL was significantly increased in women who subsequently developed gestational diabetes compared with the control group.