Short Report: Epidemiology
Family history of diabetes and effectiveness of lifestyle counselling on the cardio-metabolic risk profile in individuals at high risk of Type 2 diabetes: 1-year follow-up of the FIN-D2D project
Article first published online: 11 JAN 2012
© 2012 The Authors. Diabetic Medicine © 2012 Diabetes UK
Volume 29, Issue 2, pages 207–211, February 2012
How to Cite
Rautio, N., Jokelainen, J., Oksa, H., Saaristo, T., Peltonen, M., Puolijoki, H., Tuomilehto, J., Vanhala, M., Moilanen, L., Uusitupa, M. and Keinänen-Kiukaanniemi, S. (2012), Family history of diabetes and effectiveness of lifestyle counselling on the cardio-metabolic risk profile in individuals at high risk of Type 2 diabetes: 1-year follow-up of the FIN-D2D project. Diabetic Medicine, 29: 207–211. doi: 10.1111/j.1464-5491.2011.03388.x
- Issue published online: 11 JAN 2012
- Article first published online: 11 JAN 2012
- Accepted manuscript online: 22 JUL 2011 11:39AM EST
- Accepted 15 July 2011
- cardio-metabolic risk factors;
- family history of diabetes;
- lifestyle interventions;
- Type 2 diabetes
Diabet. Med. 29, 207–211 (2012)
Aims To investigate whether a positive family history of diabetes is associated with the effectiveness of lifestyle counselling on cardio-metabolic risk factors and glucose tolerance status in a 1-year follow-up in a cohort of Finnish men and women at high risk for Type 2 diabetes.
Methods Altogether, 10 149 individuals who had high risk of Type 2 diabetes participated in the implementation programme of the national diabetes prevention programme at baseline. One-year follow-up data were available for 2798 individuals without diabetes. Family history of diabetes was based on self-report. Lifestyle interventions were individual or groups sessions on lifestyle changes. The effectiveness of lifestyle intervention was measured as changes in cardiovascular risk factors, glucose tolerance status and incidence of Type 2 diabetes.
Results Family history was associated with the effectiveness of lifestyle intervention in men, but not in women. During the 1-year follow-up, body weight, BMI, systolic blood pressure, total cholesterol, LDL cholesterol and score for 10-year risk for fatal cardiovascular disease (SCORE) decreased and glucose tolerance status improved more in men without a family history of diabetes than in men with a family history of diabetes. Of the participating men and women, 10% and 5% developed Type 2 diabetes, respectively. Family history was not related to the incidence of Type 2 diabetes in either gender.
Conclusions Men without a family history of diabetes were more successful in responding to lifestyle counselling with regard to cardio-metabolic measurements and glucose tolerance than those with a family history of diabetes. Similar results were not seen in women. In keeping with findings from earlier studies, the prevention of Type 2 diabetes is not influenced by a family history of diabetes.