Associations of serum vitamin D concentrations with obstetric glucose metabolism in a subset of the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study cohort
Article first published online: 15 JUL 2012
© 2011 The Authors. Diabetic Medicine © 2011 Diabetes UK
Volume 29, Issue 8, pages e199–e204, August 2012
How to Cite
McLeod, D. S. A., Warner, J. V., Henman, M., Cowley, D., Gibbons, K., McIntyre, H. D. and for the HAPO Study Cooperative Research Group (2012), Associations of serum vitamin D concentrations with obstetric glucose metabolism in a subset of the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study cohort. Diabetic Medicine, 29: e199–e204. doi: 10.1111/j.1464-5491.2011.03551.x
- Issue published online: 15 JUL 2012
- Article first published online: 15 JUL 2012
- Accepted manuscript online: 12 DEC 2011 09:36AM EST
- Accepted 6 December 2011
- glucose metabolism;
- vitamin D
Diabet. Med. 29, e199–e204 (2012)
Aims To assess associations between maternal serum vitamin D concentration and glucose metabolism in a cohort of pregnant women living in an Australian subtropical environment.
Methods Cross-sectional assessment of 25-hydroxy vitamin D concentrations in 399 Hyperglycemia and Adverse Pregnancy Outcome ancillary study participants, treated at an obstetric teaching hospital in Brisbane, Australia. All patients underwent a blinded 75-g oral glucose tolerance test at 24–32 (target 28) weeks’ gestation.
Results The mean (± standard deviation) fasting plasma glucose was 4.5 ± 0.4 mmol/l. Mean (± standard deviation) serum 25-hydroxy vitamin D was 132.5 ± 44.0 nmol/l. A difference of one standard deviation in maternal 25-hydroxy vitamin D was inversely related to fasting glucose (fasting glucose lower by 0.047 mmol/l, P = 0.012) when assessed with multiple linear regression after adjusting for confounders. Maternal 25-hydroxy vitamin D correlated with β-cell function as estimated by the log-transformed homeostasis model assessment–β-cell function equation (r = 0.131, P = 0.009), but not with the homeostasis model assessment of insulin resistance.
Conclusions An association between mid-gestational 25-hydroxy vitamin D and fasting glucose was confirmed in a largely normoglycaemic and vitamin D-replete pregnant population. The correlation between 25-hydroxy vitamin D and β-cell function suggests that vitamin D may influence glucose metabolism through this mechanism. Intervention studies are required to determine causality and the role of vitamin D replacement in deficient individuals.