INPPL1 is associated with the metabolic syndrome in men with Type 1 diabetes, but not with diabetic nephropathy
Article first published online: 14 NOV 2012
© 2012 The Authors. Diabetic Medicine © 2012 Diabetes UK
Volume 29, Issue 12, pages 1589–1595, December 2012
How to Cite
Hyvönen, M. E., Ihalmo, P., Forsblom, C., Thorn, L., Sandholm, N., Lehtonen, S. and Groop, P.-H. (2012), INPPL1 is associated with the metabolic syndrome in men with Type 1 diabetes, but not with diabetic nephropathy. Diabetic Medicine, 29: 1589–1595. doi: 10.1111/j.1464-5491.2012.03668.x
- Issue published online: 14 NOV 2012
- Article first published online: 14 NOV 2012
- Accepted manuscript online: 4 APR 2012 03:10PM EST
- Accepted 29 March 2012
Diabet. Med. 29, 1589–1595 (2012)
Aims The metabolic syndrome is a frequent phenomenon in people with Type 1 diabetes and is associated with diabetic nephropathy. The aim of this study was to investigate if the INPPL1 (inositol polyphosphate phosphatase-like 1) gene encoding lipid phosphatase SHIP2 is associated with the metabolic syndrome and diabetic nephropathy in Finnish people with Type 1 diabetes.
Methods Participants were selected from the FinnDiane study for this cross-sectional study. The individuals were divided into controls without the metabolic syndrome (n = 1074) and cases with the metabolic syndrome (n = 1328), or into groups based upon their albumin excretion rate. Nine single-nucleotide polymorphisms covering the INPPL1 gene +/− 20 kb were genotyped. The associations between the single-nucleotide polymorphisms and outcome variables were analysed with the χ2 test and logistic regression.
Results Two INPPL1 single-nucleotide polymorphisms, rs2276048 (silent mutation) and rs2276047 (intronic), were associated with the metabolic syndrome in men with odds ratios of 0.23 (95% CI 0.11–0.45, P = 2.1 × 10−5), and 0.37 (0.21–0.65, P = 0.001), adjusted for age, duration of diabetes and history of smoking. When both sexes were included, these associations were less significant. No association between the genotyped single-nucleotide polymorphisms and diabetic nephropathy was observed.
Conclusions INPPL1 gene variants may contribute to susceptibility to the metabolic syndrome in men with Type 1 diabetes, but not to diabetic nephropathy.