Short Report: Pathophysiology
Femoral–gluteal adiposity is not associated with insulin sensitivity in Type 1 diabetes
Version of Record online: 7 OCT 2012
© 2012 The Authors. Diabetic Medicine © 2012 Diabetes UK
Volume 29, Issue 11, pages 1407–1411, November 2012
How to Cite
Shay, C. M., Secrest, A. M., Miller, R. G., Strotmeyer, E. S., Goodpaster, B. H., Kelsey, S. F. and Orchard, T. J. (2012), Femoral–gluteal adiposity is not associated with insulin sensitivity in Type 1 diabetes. Diabetic Medicine, 29: 1407–1411. doi: 10.1111/j.1464-5491.2012.03728.x
- Issue online: 7 OCT 2012
- Version of Record online: 7 OCT 2012
- Accepted manuscript online: 4 JUN 2012 12:12PM EST
- Accepted 1 June 2012
Aims To quantify and compare associations between femoral–gluteal adiposity and insulin sensitivity in adults with Type 1 diabetes mellitus with adults with normal glucose tolerance.
Methods Individuals with Type 1 diabetes (n = 28) were recruited from the Pittsburgh Epidemiology of Diabetes Complication study, a 24-year prospective study of childhood-onset diabetes, and compared cross-sectionally with individuals with normal glucose tolerance (n = 56) of similar age, sex and BMI. Insulin sensitivity was defined as whole-body glucose disposal measured by hyperinsulinaemic–euglycaemic clamps. Adiposity was quantified by dual energy X-ray absorptiometry.
Results Individuals with Type 1 diabetes exhibited lower insulin sensitivity (5.8 vs. 8.2 mg min−1 kg fat-free mass−1, P < 0.01), lower total fat mass (20.1 vs. 29.0 kg, P < 0.001) and lower proportional leg fat mass (36.0 vs.37.7%, P = 0.03), but similar proportional trunk fat (% trunk fat mass) compared with individuals with normal glucose tolerance. Overall, results from linear regression demonstrated that higher % leg fat mass (P < 0.01) and lower % trunk fat mass (P < 0.01) were independently associated with lower insulin sensitivity after adjustments for age, sex, height, total fat mass (kg) and diabetes status. Higher % leg fat mass was independently associated with higher insulin sensitivity in individuals with normal glucose tolerance (P < 0.01) after similar adjustment; significant associations were not observed in Type 1 diabetes.
Conclusions Reduced insulin sensitivity is a prominent feature of Type 1 diabetes and is associated with total and abdominal adiposity. Compared with adults with normal glucose tolerance, leg fat mass does not show any positive association with insulin sensitivity in Type 1 diabetes.