Table S1. Summary of setting, design, objectives, participants and intervention characteristics for the non-RCT studies.

Table S2. Risk of bias in RCTs.

Table S3. Summary of key findings of non-RCTstudies.

Appendix S1. MEDLINE (Ovid) search strategy.

Appendix S2. Checklist for assessing the content and quality of papers.

dme3749_sm_AppendixS1.doc25KSupporting info item
dme3749_sm_AppendixS2.doc92KSupporting info item
dme3749_sm_TableS1.doc50KSupporting info item
dme3749_sm_TableS2.doc114KSupporting info item
dme3749_sm_TableS3.doc47KSupporting info item

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